Powder: -20°C for 3 years | In solvent: -80°C for 1 year
STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM.
説明 | STL127705 (Compound L) is a potent Ku 70/80 heterodimer protein inhibitor and inhibits Ku70/80-DNA interaction with IC50 of 3.5 μM. STL127705 inhibits the activation of Ku-dependent DNA-PKCS kinase with IC50 of 2.5 μM. |
ターゲット&IC50 | Ku 70/80:3.5 μM , DNA-PKCS:2.5 μM |
別名 | Compound L, 7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
分子量 | 437.42 |
分子式 | C22H20FN5O4 |
CAS No. | 1326852-06-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 60 mg/ml (137.17 mM)
You can also refer to dose conversion for different animals. 詳細
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STL127705 1326852-06-5 DNA Damage/DNA Repair Others PI3K/Akt/mTOR signaling DNA-PK DNA-PKCS kinase STL-127705 inhibit STL 127705 H1299 cells DNA-dependent protein kinase Compound L Inhibitor antiproliferative 7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Apoptosis SF-767 cells anticancer inhibitor