Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
説明 | CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM). |
ターゲット&IC50 | mTOR:21nM, DNA-PK:13 nM |
In vitro | The IC50 values for CC-115 are >10 μM against a panel of CYP enzymes and >33 μM for the hERG ion channel. When screened in a single point assay at 10 μM against a Cerep receptor and enzyme panel only one target was inhibited >50% (PDE3, IC50 = 0.63 μM). |
In vivo | CC-115 shows good PK profiles across multiple species with 53%, 76%, and 100% oral bioavailability in mouse, rat, and dog, respectively. CC-115, with favorable physicochemical and pharmacokinetic properties, demonstrates mTOR pathway inhibition and tumor growth inhibition, as well as a good safety profile, suitable for Clinicalal development. |
細胞研究 | Freshly isolated CLL cells are treated with different concentrations of CC-115 for 30 minutes. Subsequently, the cells are exposed to 5-Gy γ-radiation or treated with 10 µg/mL bleomycin (EMD Millipore, Billerica, MA) and incubated for 30 minutes, and cell lysates are made. (Only for Reference) |
別名 | CC 115 |
分子量 | 336.35 |
分子式 | C16H16N8O |
CAS No. | 1228013-15-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 62 mg/mL (184.3 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CC-115 1228013-15-7 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling PI3K DNA-PK mTOR DNA-dependent protein kinase CC115 inhibit CC 115 Inhibitor Mammalian target of Rapamycin inhibitor