Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Scopoletin (Esculetin 6-methyl ether) is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 7,000 | |||
25 mg | 在庫あり | ¥ 10,000 | |||
50 mg | 在庫あり | ¥ 14,000 | |||
100 mg | 在庫あり | ¥ 20,500 | |||
200 mg | 在庫あり | ¥ 29,500 | |||
500 mg | 在庫あり | ¥ 49,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,000 |
説明 | Scopoletin (Esculetin 6-methyl ether) is a plant growth factor derived from the root of Scopolia carniolica, inhibits of acetylcholinesterase (AChE). |
In vivo | Female BALB/c mice were treated with Mogroside V (2.5, 5 and 10 mg/kg) for 1 h prior to intranasal injection of LPS (10 μg in 50 μl). After 12 h, airway inflammation in the ALI model was determined by the wet/dry weight (W/D) ratio, myeloperoxidase (MPO) activity of lung tissue, leukocyte recruitment and cytokine levels in the bronchoalveolar lavage fluid (BALF). Additionally, lung tissue was examined by histology and western blotting to investigate the changes in pathology and the signalling in the presence and absence of Mogroside V. Mogroside V at 5 and 10 mg/kg inhibited airway inflammation induced by LPS as measured by the decrease in the histological changes (44 and 67.3% reduction in lung injury score, respectively), a 28.9 and 55.3% reduction in lung MPO activity, and inflammatory cell counts, interleukin-1β (IL-1β, 382 and 280 pg/ml, respectively), IL-6 (378 and 232 pg/ml, respectively) and tumor necrosis factor-α (TNF-α, 12.5 and 7.8 ng/ml, respectively) levels in the BALF. Additionally, Mogroside V treatment reduced the activation of cyclooxygenase 2 (COX-2), inducible NO synthase (iNOS), and the nuclear factor (NF)-κB. |
植物由来 |
別名 | Chrysatropic acid, Esculetin 6-methyl ether, Gelseminic acid, 6-Methylesculetin |
分子量 | 192.17 |
分子式 | C10H8O4 |
CAS No. | 92-61-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 32 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Scopoletin 92-61-5 Apoptosis Neuroscience AChE AChR Inhibitor Chrysatropic acid Cholinesterase (ChE) inhibit Esculetin 6-methyl ether Gelseminic acid 6-Methylesculetin inhibitor