Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus.
説明 | Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
ターゲット&IC50 | AMPA:190 nM |
In vivo |
Selurampanel (3 mg/kg i.v.) a mouse plasma half-life of 3.3 h is determined, with a moderate volume of distribution (Vdss=1.3 L/kg) and a low clearance of 5.4 mL/min▪kg.[5] Selurampanel potently and dose-dependently antagonizes maximal electroshock seizure-induced generalized tonic-clonic seizures in mice with an ED50 value around 7 mg/kg after 1 h pre-treatment.[5] |
別名 | BGG-492, BGG 492, BGG492 |
分子量 | 377.42 |
分子式 | C16H19N5O4S |
CAS No. | 912574-69-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.5 mg/mL (72.86 mM)
You can also refer to dose conversion for different animals. 詳細
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Selurampanel 912574-69-7 Membrane transporter/Ion channel Neuroscience iGluR BGG-492 BGG 492 BGG492 Inhibitor inhibitor inhibit