Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM).
説明 | Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM). |
ターゲット&IC50 | CDK19:80 nM (Kd) , CDK8:140 nM (Kd) |
In vitro | Senexin B inhibits CDK8/19 in low nanomolar range[1] |
In vivo | In a spleen-to-liver colon cancer metastasis model of syngeneic mouse CT26 tumors, Senexin B treatment of mice had the same effect as CDK8 knockdown in tumor cells: suppression of metastatic growth in the liver without a significant effect on primary tumor growth in the spleen[1]. |
分子量 | 450.53 |
分子式 | C27H26N6O |
CAS No. | 1449228-40-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 6 mg/mL (13.32 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Senexin B 1449228-40-3 Cell Cycle/Checkpoint CDK Inhibitor inhibitor inhibit