Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 10,500 | |||
10 mg | 在庫あり | ¥ 13,500 | |||
25 mg | 在庫あり | ¥ 33,500 | |||
50 mg | 在庫あり | ¥ 66,500 | |||
100 mg | 在庫あり | ¥ 91,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,000 |
説明 | Sertindole (Lu 23-174) is an atypical antipsychotic that binds to dopamine D2 receptors and the serotonin (5-HT) receptor subtypes 5-HT1D, 5-HT2A, and 5-HT2C (Kds = 2.7, 20, 0.14, and 6 nM, respectively) |
In vivo | In vivo, sertindole (10 mg/kg) increases extracellular dopamine, acetylcholine (ACh), and glutamate levels in the medial prefrontal cortex in conscious rats[1].Sertindole (2.5 mg/kg) reverses ketamine-induced impairments in the extradimensional shift stage of the attentional set-shifting task (ASST) in rats[2].It reverses phencyclidine (PCP)-induced selective reversal learning deficits in rats and subchronic PCP-induced deficits in the novel object recognition task in mice[3]. |
動物実験 | Rats were treated acutely with vehicle or drugs, and extracellular levels of neurotransmitters were assessed by microdialysis in freely moving animals[1]. |
別名 | Lu 23-174 |
分子量 | 440.94 |
分子式 | C24H26ClFN4O |
CAS No. | 106516-24-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (113.39 mM)
You can also refer to dose conversion for different animals. 詳細
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Sertindole 106516-24-9 Autophagy GPCR/G Protein Neuroscience Adrenergic Receptor 5-HT Receptor Dopamine Receptor Jurkat A172 MCF-7 anti-proliferative activity U118-MG MKN45 Bel-7402 SW480 COLO205 SUM159 NCI-H661 SW620 Beta Receptor Lu 23-174 CCRF-CEM HCT-15 SGC-7901 801-D Serotonin Receptor 5-hydroxytryptamine Receptor NCI-H460 NCI-H446 U87-MG BGC-823 HT-29 K562 inhibit U251 MCF-10A T47D AGS antipsychotic activity A549 HepG2 Inhibitor inhibitor