Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
5 mg | 約4-6 週間 | ¥ 47,500 |
10 mg | 約4-6 週間 | ¥ 72,000 |
25 mg | 約4-6 週間 | ¥ 110,000 |
50 mg | 約4-6 週間 | ¥ 169,500 |
説明 | Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siramesine can induce rapid cell death in a number of cell lines at concentrations above 20 μM. In HaCaT cells, cell death was accompanied by caspase activation, rapid loss of mitochondrial membrane potential (MMP), cytochrome c release, cardiolipin peroxidation and typical apoptotic morphology, whereas in U-87MG cells most apoptotic hallmarks were not notable, although MMP was rapidly lost |
別名 | Lu 28-179 |
分子量 | 454.58 |
分子式 | C30H31FN2O |
CAS No. | 147817-50-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Siramesine 147817-50-3 GPCR/G Protein Sigma receptor Inhibitor lysosomes inhibit death cathepsin Sigma Receptor mitochondria selectivity Lu 28-179 cancer inhibitor