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T16777 |
ROC-325
|
|
Apoptosis
,
Autophagy
|
|
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. |
|
T1885 |
Siramesine hydrochloride
|
Lu 28-179 hydrochloride |
Ferroptosis
,
Sigma receptor
,
lysosomal autophagy
|
|
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo. |
|
T4620 |
Siramesine
|
Lu 28-179 |
Sigma receptor
|
|
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram... |
|
T60036 |
ML-SA5
|
|
Autophagy
|
|
ML-SA5 is an MCOLN1 agonist and arrests autophagic flux by perturbing fusion between autophagosomes and lysosomes. |
|
T11142 |
EACC
|
|
Autophagy
|
|
EACC, a reversible autophagy inhibitor, selectively impedes Stx17, an autophagosome-specific SNARE, from translocating, hence obstructing the fusion between autophagosomes and lysosomes. This compound effectively halts a... |
|
T77945 |
TriGalNAc CBz
|
|
LYTACs
|
|
TriGalNAc CBz is a GalNAc derivative. As an ASGPR ligand, tri-GalNAc targets lysosomes in mRNA drug delivery and LYTAC studies.L-DABA hydrobromide. |
|
T77553 |
MHI-148
|
IR-808 |
|
|
MHI-148 is a tumor-targeting near-infrared heptamethylenecarbocyanine dye for the detection, diagnosis, and study of cancer.MHI-148 is taken up and accumulates in the lysosomes and mitochondria of tumor cells but is not ... |
|
T1908 |
MHY1485
|
|
mTOR
,
Autophagy
|
|
MHY1485 is a mTOR activator. It inhibits the autophagic process by inhibition of fusion between autophagosomes and lysosomes, leading to the accumulation of LC3II protein and enlarged autophagosomes. |
|
T21992 |
Vacuolin-1
|
|
PI3K
,
Autophagy
|
|
Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits ... |
|
T37885 |
1-Dodecylimidazole
|
|
Antifungal
|
|
1-Dodecylimidazole (N-Dodecylimidazole) is a chemical compound that serves as a cytotoxic agent and lysosomotropic detergent. It induces cell death through acid-dependent accumulation in lysosomes, which disrupts the lys... |
|
T33674 |
NIM-7
|
NIM7 |
|
|
NIM-7 is a fluorescent probe, allowing lipid droplets and lysosomes to be labelled simultaneously and with high specificity, being visualized readily through yellow and red fluorescence, using different excitation and de... |
|
T35922 |
NAADP (sodium salt)
|
|
|
|
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a secondary messenger that induces calcium mobilization. It induces calcium release from endosomes and lysosomes via two-pore channel 2 (TPC2) and TPC1, which then... |
|
T39855 |
LysoTracker Red
|
LysoTracker Red DND-99 |
|
|
LysoTracker Red (LysoTracker Red DND-99) is a paraformaldehyde fixable probe that concentrates into acidic compartments of cells and tissues. LysoTracker Red is an indicator of cell death in a manner similar to other st... |
|
T35930 |
Ganglioside GM2 Mixture (sodium salt)
|
|
|
|
Ganglioside GM2 is a glycosphingolipid component of cellular membranes, primarily the plasma membrane. Levels of ganglioside GM2 are elevated in the brain of patients with Sandhoff disease, as well as feline and mouse mo... |
|
T78371 |
Ac2-26 ammonium
|
|
|
|
Ac2-26 ammonium, an N-terminal peptide of annexin 1, exhibits anti-inflammatory properties, reduces IKKβ protein levels in lysosomes via chaperone-mediated autophagy (CMA), improves lung ischemia-reperfusion injury outco... |
|
T79556 |
NDBM
|
|
Autophagy
|
|
NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and ... |
|
T36370 |
4-Methylumbelliferyl-α-L-Iduronide (free acid)
|
|
|
|
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and hepa... |
|
T73550 |
CUR5g
|
|
|
|
CUR5g, a potent autophagy inhibitor, selectively prevents autophagosome degradation in cancer cells by hindering the fusion of autophagosomes with lysosomes. It disrupts the recruitment of STX17 to autophagosomes through... |
|
T77186 |
Zilovertamab vedotin
|
|
|
|
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate consisting of the humanized monoclonal antibody zilovertamab linked to the anti-microtubule cytotoxin monomethyl auristatin E (MMAE). Upon binding to ROR1... |
|
T77876 |
Py-MAA-Val-Cit-PAB-MMAE
|
AAJ8D6-PY-Val-Cit-MMAE |
|
|
Py-MAA-Val-Cit-PAB-MMAE (AAJ8D6-PY-Val-Cit-MMAE) serves as an ADC linker for Zapadcine-3a, a broad-spectrum anti-TRAILR2 ADC with antineoplastic properties. By targeting TRAILR2, Zapadcine-3a is internalized into the lys... |
|
T77131 |
Clervonafusp alfa
|
|
|
|
Clervonafusp alfa (VAL-1221) is a fusion protein designed to target both cytosolic and lysosomal glycogen, thereby addressing the underlying mechanisms of Pompe disease. This compound integrates the Fab segment of a cell... |
|
T36805 |
TPC2-A1-N
|
TPC2-A1-N |
|
|
TPC2-A1-N is a novel, lipophilic, membrane permeable isoform-selective small molecule agonist of two-pore channel 2 (TPC2). TPC2-A1-N plays its role by mimicking the physiological actions of NAADP and PI(3,5)P2 through i... |
|
T36806 |
TPC2-A1-P
|
TPC2-A1-P |
|
|
TPC2-A1-P is a potent, membrane-permeable agonist of the two-pore channel 2 (TPC2), exhibiting an EC50 of 10.5 μM. It exerts its effects by mimicking the physiological actions of PI(3,5)P2, and demonstrates greater effic... |
