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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9339 | Stafia-1 | STAT | |
Stafia-1 is a potent STAT5a inhibitor ( IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members. | |||
T11960 | MBM-55 | GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase | |
T9020 | GSK620 | Epigenetic Reader Domain | |
GSK620 is a pan-BD2 inhibitor, which shows an anti-inflammatory phenotype in human whole blood with excellent broad selectivity, developability, and in vivo oral pharmacokinetics.GSK620 is highly selective for the BET-BD... | |||
T21331 | SAR-020106 | Chk | |
SAR-020106 is a potent, ATP-competitive, and selective CHK1 inhibitor with an IC50 of 13.3 nmol/L on the isolated human enzyme. | |||
T9470 | HPK1-IN-7 | MAPK | |
HPK1-IN-7 is an orally active HPK1 inhibitor. It shows selectivity against IRAK4 (59 nM) and GLK (140 nM). | |||
T28628 | RVX-297 | RVX297 | Epigenetic Reader Domain |
RVX-297 is a BD2 selective inhibitor of BET bromodomains. RVX-297 preferentially binds to the BD2 domains of the BET bromodomain and Extra Terminal (BET) family of protein. | |||
T11696 | Ivachtin | Caspase-3 Inhibitor VII | Caspase |
Ivachtin (Caspase-3 Inhibitor VII) is a nonpeptide, noncompetitive and reversibl caspase-3 inhibitor(IC50 = 23 nM) and is a modest inhibitor of the remaining caspases. | |||
T4199 | Desmethyl-VS-5584 | PI3K , mTOR | |
Desmethyl-VS-5584 is a dimethyl analog of VS-5584, which is a novel and highly selective PI3K/mTOR kinase inhibitor for the treatment of cancer. | |||
T5405 | BI-1347 | CDK | |
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model. | |||
T28352 | PDE9-IN-(S)-C33 | (S)-C33 | PDE |
PDE9-IN-(S)-C33 ((S)-C33) is a potent and selective inhibitor of PDE9 (IC50 = 11 nM). PDE9-IN-(S)-C33 can be used for central nervous system diseases and diabetes research. | |||
T9564 | IRE1α kinase-IN-1 | IRE1 | |
IRE1α kinase-IN-1 is a highly selective IRE1α (ERN1) inhibitor, with an IC50 of 77 nM. It displays 100-fold selectivity for IRE1α over the IRE1β isoform. It inhibits ER stress-induced IRE1α oligomerization and autophosph... | |||
T1885 | Siramesine hydrochloride | Lu 28-179 hydrochloride | Ferroptosis , Sigma receptor , lysosomal autophagy |
Siramesine hydrochloride (Lu 28-179 hydrochloride) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of Y cells and to exhibit a potent anticancer activity in vivo. | |||
T15418 | GS-6201 | CVT-6883 | Adenosine Receptor |
GS-6201 (CVT-6883) is a selective antagonist of adenosine A2B receptor. GS-6201 shows high affinity and selectivity for the human adenosine A2B receptors with a Ki of 22 nM. | |||
T6658 | SB-408124 | OX Receptor | |
SB408124 is a non-peptide antagonist for OX1 receptor with Ki of 57 nM and 27 nM in both whole cell and membrane, respectively, exhibits 50-fold selectivity over OX2 receptor. | |||
T6493 | Escitalopram Oxalate | Cipralex,(S)-(+)Citalopram oxalate | Others , 5-HT Receptor , Serotonin Transporter |
Escitalopram Oxalate ((S)-(+)Citalopram oxalate) is a selective serotonin (5-HT) reuptake inhibitor (SSRI) with Ki of 0.89 nM. | |||
T4620 | Siramesine | Lu 28-179 | Sigma receptor |
Siramesine (Lu 28-179)(Lu 28-179) is a selective sigma-2 receptor agonist, which has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo.lysosome-destabilizing agent siram... | |||
T14547 | JWG-071 | JWG071,JWG 071 | ERK , Epigenetic Reader Domain |
JWG-071, the first reported chemical probe for ERK5 kinase selectivity, is a BET-selective inhibitor with a 1 μM BRD4 IC that enhances both ERK5 activity and BRD4 selectivity. | |||
T6940 | PHA-767491 hydrochloride | CAY10572,PHA-767491,PHA767491 HCl,CAY-10572 hydrochloride | Apoptosis , GSK-3 , CDK |
PHA-767491 hydrochloride (CAY-10572 hydrochloride) is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivity against CDK5 and MK... | |||
T14947 | CHDI-390576 | HDAC | |
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity ... | |||
T16989 | Tarafenacin D-tartrate | SVT-40776 D-tartrate | Others |
Tarafenacin D-tartrate is a highly selective M3 muscarinic receptor antagonist (Ki= 0.19 nM), ~200 fold selectivity over the M2 receptor. | |||
T19671 | AZ31 | AZ 31,AZ-31 | ATM/ATR |
AZ31 is an ATM inhibitor with potency, high selectivity, and oral activity.AZ31 inhibits ATM enzymes, intracellular ATM, with IC50 values of <1.2 nM and 46 nM, respectively.AZ31 exhibits excellent ATR selectivity, PIKK f... | |||
T2356 | Ro-3306 | Apoptosis , ERK , SGK , PKA , CDK , PKC | |
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinases. | |||
T2435 | EPZ011989 | Histone Methyltransferase | |
EPZ011989 is a effective, specific orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 Y646 and EZH2 wt; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. | |||
T10277 | AL 8697 | p38 MAPK | |
AL 8697 is a selective p38α MAPK inhibitor (IC50 = 6 nM) with 14-fold selectivity over p38β (IC50 = 82 nM) and 300-fold selectivity over a panel of 91 kinases. AL 8697 has anti-inflammatory activity. | |||
T6286 | RGFP966 (E-isomer) | HDAC | |
RGFP966 is an HDAC3 inhibitor with IC50 of 0.08 μM, exhibits > 200-fold selectivity over other HDAC. | |||
T3049 | TPCA-1 | GW683965,IKK2 Inhibitor IV,TPCA1 | Apoptosis , IκB/IKK , STAT |
TPCA-1 (TPCA1) is an effective and specific IKK-2 inhibitor (IC50: 17.9 nM); shows >22-fold selectivity over IKK-1 and >550-fold selectivity over others kinases and enzymes. | |||
T6054 | GSK256066 | PDE | |
GSK256066 is a selective PDE4B(equal affinity to isoforms A-D) inhibitor with IC50 of 3.2 pM, >380, 000-fold selectivity versus PDE1/2/3/5/6 and >2500-fold selectivity against PDE4B versus PDE7.Phase 2. | |||
T21703 | 4-Chlorophenylguanidine hydrochloride | Others | |
4-Chlorophenylguanidine hydrochloride is a potent inhibitor of urokinase selectivity. | |||
T26109 | Robenacoxib | Onsior | COX |
Robenacoxib (Onsior) is a non-steroidal compound with strong selectivity for cyclooxygenase-2 and anti-inflammatory activity. | |||
T1830 | BX795 | IκB/IKK , Chk , CDK , c-Kit , PDK , Autophagy | |
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respectively. Meanwhile, the selectivity for PDK1 is 100-fold than... | |||
T6064 | UK-383367 | UK 383367 | Procollagen C Proteinase |
UK-383367 is a procollagen C-proteinase inhibitor with IC50 of 44 nM, has excellent selectivity over MMPs. | |||
T13312L | Seviteronel | VT-464 | Others |
Seviteronel is an effective CYP17 lyase inhibitor (h-Lyase IC50=69 nM). In a hamster model of androgen biosynthesis inhibition, it demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral... | |||
T39573 | GSK251 | PI3K | |
GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode. | |||
T36287 | Pirtobrutinib | BTK | |
Pirtobrutinib (LOXO-305) is an advanced BTK inhibitor that displays high selectivity and operates through a non-covalent mechanism. This compound effectively inhibits various BTK C481 substitution mutations, leading to t... | |||
T16936 | SS-208 | HDAC | |
SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes. | |||
T19917 | Gepirone | 5-HT Receptor | |
Gepirone is a 5-HT1A receptor agonist belonging to the buspirone family. Gepirone HCl possesses greater selectivity for the 5-HT1A receptor than SSRIs. | |||
T8651 | CAL-101 | (S)-2-(1-(9H-Purin-6-ylamino)ethyl)-5-fluoro-3-phenylquinazolin-4(3H)-one,GS-1101,Idelalisib | PI3K |
CAL-101 (Idelalisib) is a selective inhibitor of p110δ(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110δ than p110α/β/γ, and 400- to 4000-fold more selectivity to p110δ than... | |||
T68134 | Ro-3201195 | p38 MAPK | |
Ro-3201195 is a novel orally available p38 MAPK inhibitor with high selectivity. | |||
T22990 | ML-090 | Fluoflavine | NADPH-oxidase , Others |
ML-090 is NOX1-specific inhibitor(IC50 = 90 nM) which is >100 selectivity for NOX1 over NOX2, NOX3, NOX4 (all IC50s >10 μM). | |||
T6378 | AMG-458 | AMG 458 | c-Met/HGFR |
AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells. | |||
T6358 | 1-Azakenpaullone | azakenpaullone | GSK-3 |
1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25. | |||
T36631 | BAY-6035 | MEK , Histone Methyltransferase | |
BAY-6035 is an inhibitor of SET and MYND domain-containing protein 3 (SMYD3). BAY-6035 has more than 100-fold selectivity over other histone methyltransferases. | |||
T6757 | AMG319 | PI3K | |
AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2. | |||
T6306 | Erteberel | LY500307 | Estrogen Receptor/ERR , Estrogen/progestogen Receptor |
Erteberel (LY500307) is a potent, selective estrogen receptor β agonist with EC50 of 0.66 nM, 32-fold selectivity against estrogen receptor α. Phase 2. | |||
T16777 | ROC-325 | Apoptosis , Autophagy | |
ROC-325 is an effective and orally active inhibitor of autophagy with anticancer activity. ROC-325 induces renal cell carcinoma apoptosis and exhibits favorable selectivity. | |||
T5503 | IPSU | OX Receptor | |
IPSU is an antagonist of OX2 receptor. IPSU Exhibits approximately six-fold selectivity for OX2 versus OX1 receptors. | |||
T6208 | AS-252424 | Casein Kinase , PI3K | |
AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα. | |||
T26531 | ABT-963 | ABT963 | |
ABT-963 is a cyclooxygenase 2 (COX-2) inhibitor potentially for the treatment of osteoarthritis and pain. ABT-963 has excellent selectivity in human whole blood, high oral anti-inflammatory potency in vivo, and gastric s... | |||
T23602 | ABC99 | ABC 99,ABC-99 | Wnt/beta-catenin |
ABC99 is a selective irreversible inhibitor of the wnt-deacylating enzyme. ABC99 inhibited NOTUM (IC50: 13 nM). It also showed excellent selectivity across the serine hydrolase family. | |||
T23316 | SB 218795 | Neurokinin receptor | |
SB 218795 is an effective and selective antagonist of NK3 with a Ki 13 nM for hNK3 which is about 90-fold and 7000-fold selectivity over hNK2 and hNK1. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T0185 | Escitalopram | Seroplex,S-(+)-Citalopram,(S)-Citalopram | Dopamine Receptor , 5-HT Receptor , Serotonin Transporter , Adrenergic Receptor , AChR , Norepinephrine , Histamine Receptor |
Escitalopram (Seroplex) is a furancarbonitrile that is one of the SEROTONIN UPTAKE INHIBITORS used as an antidepressant. The drug is also effective in reducing ethanol uptake in alcoholics and is used in depressed patien... | |||
T2826 | Asaraldehyde | Asarylaldehyde,2,4,5-trimethoxy-Benzaldehyde,Asaronaldehyde | COX |
Asaraldehyde (2,4,5-trimethoxy-Benzaldehyde), a natural COX-2 inhibitor, exhibits 17-fold selectivity than COX-1. | |||
T3S1251 | Neoruscogenin | ROR | |
1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors. | |||
T6512 | G-418 disulfate | Geneticin,G418 Sulfate,Antibiotic G-418 sulfate,Geneticin sulfate | Antibacterial , Antibiotic |
G-418 disulfate (Geneticin sulfate) is an aminoglycoside antibiotic, an inhibitor of protein synthesis with eukaryotic selectivity. G-418 disulfate blocks peptide synthesis by inhibiting peptide chain elongation. | |||
T7472 | 7-Hydroxyflavone | P450 | |
7-Hydroxyflavone is a potent inhibitor of CYP1A1 with a Ki value of 0.015 μM and exhibits 6-fold greater selectivity for CYP1A1 over CYP1A2.with anti-inflammatory activity | |||
T0665 | Xanthine | 2,6-Dihydroxypurine,Isoxanthine | Endogenous Metabolite , Adenosine Receptor |
Xanthine (Isoxanthine) is a product on the pathway of purine degradation. Xanthine is subsequently converted to uric acid by the action of the Xanthine oxidase enzyme. Xanthine is found in most body tissues and fluids in... | |||
T11041 | Dihydro-β-erythroidine hydrobromide | DHβE hydrobromide | Others |
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAC... | |||
T74005 | Urolithin D | ||
Urolithin D acts as a competitive and reversible antagonist for EphA receptors, displaying selectivity within its class [1]. | |||
TN4788 | Pierreione B | mTOR | |
Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cytotoxicity. | |||
TN1852 | Lancifodilactone F | HIV Protease | |
Lancifodilactone F exerts minimal cytotoxicity against C8166 cells (CC50 > 200 microg/mL) and shows anti-HIV activity with EC50 = 20.69 +/- 3.31 microg/mL and a selectivity index > 6.62. | |||
TN2360 | Falcarinol | Falcarinol,Panaxynol | HSP |
Falcarinol, also known as Panaxynol, is a naturally occurring compound that acts as an orally active inhibitor of Hsp90. It effectively targets both the N-terminal and C-terminal regions of Hsp90, displaying high selecti... | |||
TN3428 | Aphadilactone C | Others | |
Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, ... | |||
T36303 | Psammaplin A | ||
Psammaplin A, a marine metabolite, functions as a robust inhibitor of HDAC and DNA methyltransferases, displaying notable potency and selectivity as a DAC1 inhibitor, with an IC50 value of 0.9 nM. It exhibits antimicrobi... | |||
T75651 | Rivulariapeptolides 988 | ||
Rivulariapeptolides 988 demonstrates significant potency and selectivity as a serine protease inhibitor, exhibiting IC50 values of 95.46 nM for chymotrypsin, 15.29 nM for elastase, and 85.50 nM for proteinase K [1]. | |||
T72802 | Spongionellol A | ||
Spongionellol A, an inhibitor of MDR1 (p-glycoprotein), exhibits significant cytotoxicity and selectivity towards prostate cancer cells through the induction of caspase-dependent apoptosis. This compound is valuable for ... | |||
T75630 | Ganoderic acid Mf | ||
Ganoderic acid Mf, an antitumor triterpenoid, selectively induces apoptosis in cancer cells through a mitochondria-mediated pathway while demonstrating high selectivity between normal and cancer cells. It also arrests th... | |||
T79975 | Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside | HBV | |
Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside (Compound 1), a lignan with anti-HBV activity, exhibits selectivity by targeting the HBV surface antigen (HBsAg) with an IC50 of 0.58 mM, whereas its activity ag... | |||
T73072 | PTP1B-IN-20 | ||
PTP1B-IN-20 is a selective PTP1B (protein tyrosine phosphatase 1B) inhibitor, exhibiting an IC50 of 1.05 μM, and demonstrates selectivity over TCPTP (T-cell protein tyrosine phosphatase), which has an IC50 of 78.0 μM. Th... | |||
T82031 | Isoguaiacin | ||
Isoguaiacin, a natural product [1], exhibits (hass) the potential to be (to exist as) an (a) effective pharmacological agent due to its (its) ability to inhibit (the inhibition of) mushroom tyrosinase. This (The) inhibit... | |||
T75436 | Jatrorrhizine hydroxide | ||
Jatrorrhizine hydroxide, an alkaloid derived from Coptis chinensis, exhibits a range of biological activities including neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties [1]. It acts as a potent ... | |||
T83913 | Mitraciliatine | ||
Mitraciliatine, an alkaloid discovered in M. speciosa (Kratom in Thai), acts as a partial agonist for the μ-opioid receptor (MOR) and an agonist for the κ-opioid receptor (KOR), demonstrating selectivity for these recept... | |||
T37876 | Fengycin | ||
Fengycin, a cyclic lipopeptide, functions as an agricultural fungicide by exhibiting an anti-fungal infection effect through damaging the target's cell membrane[1]. |
カタログ番号 | 製品名 | Species | Expression System |
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TMPY-02710 | CANT1 Protein, Human, Recombinant (His) | Human | HEK293 |
CANT1(calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yie... | |||
TMPY-02975 | CANT1 Protein, Human, Recombinant (hFc) | Human | HEK293 |
CANT1(calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yie... | |||
TMPJ-00922 | DCK Protein, Human, Recombinant (His & T7) | Human | E. coli |
Deoxycytidine Kinase (DCK) is a member of the DCK/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanos... | |||
TMPJ-01001 | CCL11 Protein, Human, Recombinant | Human | E. coli |
C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of all... | |||
TMPY-00782 | ECE2 Protein, Human, Recombinant (hFc) | Human | HEK293 |
Endothelin-converting enzyme 2, also known as ECE-2, is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme. Endothelin-converting enzymes (ECEs) are the key enzy... | |||
TMPY-01891 | ECE2 Protein, Human, Recombinant (His) | Human | HEK293 |
Endothelin-converting enzyme 2, also known as ECE-2, is a metalloprotease that possesses many properties consistent with it being a neuropeptide-processing enzyme. Endothelin-converting enzymes (ECEs) are the key enzy... | |||
TMPH-02301 | VPS35 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transm... | |||
TMPH-00818 | Delta-theraphotoxin-Hm1a Protein, Heteroscodra maculata, Recombinant (His & Myc & SUMO) | Heteroscodra maculata | E. coli |
Gating-modifier toxin that potently inhibits inactivation of the mammalian Nav1.1/SCN1A sodium channel (EC(50)=38 nM). Also moderately inhibits inactivation of Nav1.2/SCN2A (EC(50)=236 nM) and Nav1.3/SCN3A (EC(50)=220 nM... |
カタログ番号 | 製品名 | ||
---|---|---|---|
L9411 | Cysteine Covalent Library | 70 compounds | |
The cysteine covalent library contains 70 compounds. | |||
L2152 | Targeted Therapy Drug Library | 119 compounds | |
119 tumor-targeted drugs that can be used for high-throughput and high-content screening. | |||
L9610 | Cyclic Peptide Library | 55 compounds | |
55 species of cyclic peptide molecules for high-throughput and high-content screening; | |||
L7400 | Sodium Channel Blocker Library | 118 compounds | |
A unique collection of 118 sodium channel blockers and agonists for high throughput and high content screening; | |||
L9600 | Peptide Compound Library | 791 compounds | |
791 peptides can be used in peptide drug development and signaling transduction and mechanism study; |