Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 7,500 | |||
10 mg | 在庫あり | ¥ 11,000 | |||
25 mg | 在庫あり | ¥ 17,500 | |||
50 mg | 在庫あり | ¥ 23,500 | |||
100 mg | 在庫あり | ¥ 32,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 8,500 |
説明 | Stachydrine (N,N-Dimethyl-L-proline) is a major constituent of Chinese herb leonurus heterophyllus sweet used to promote blood circulation and dispel blood stasis. Stachydrine (N,N-Dimethyl-L-proline) can inhibit the NF-κB signal pathway. Stachydrine (N,N-Dimethyl-L-proline) is a biomarker for the consumption of citrus fruits. |
In vitro | Various concentrations of stachydrine intervention (10(-6) - 10(-4) mol/L) showed better anti-hypertrophic effect and decreased the number of ROS positive myocardial cell (P<0.05). Meanwhile, intervention of stachydrine significantly suppressed the level of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus (P<0.05). |
細胞研究 | Myocardial cells of neonatal rats were incubated with angiotensin II for 48 hours to establish myocardial cell hypertrophy models. The cell surface area and protein/DNA ratio were detected as index for hypertrophy of myocardial cells. ROS positive myocardial cell were counted by means of flow cytometry, the expression of p-IkappaB (ser32) protein in the cytosol and NF-kappaB (p65) protein in the nucleus were also detected by Western blot. |
別名 | Methyl hygrate betaine, L-stachydrine, Proline betaine, N,N-Dimethyl-L-proline |
分子量 | 143.18 |
分子式 | C7H13NO2 |
CAS No. | 471-87-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 26 mg/mL (181.59 mM)
H2O: 32 mg/mL (223.49 mM)
You can also refer to dose conversion for different animals. 詳細
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Stachydrine 471-87-4 Metabolism NF-Κb Endogenous Metabolite NF-κB Methyl hygrate betaine Inhibitor Nuclear factor-κB L-stachydrine Proline betaine inhibit Nuclear factor-kappaB N,N-Dimethyl-L-proline inhibitor