Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 9,000 | |||
25 mg | 在庫あり | ¥ 20,500 | |||
50 mg | 在庫あり | ¥ 35,500 | |||
100 mg | 在庫あり | ¥ 52,500 |
説明 | TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively. |
ターゲット&IC50 | AChE:0.3 μM |
In vitro | The effects of TAE-1 on differentiated human SH-SY5Y neuronal cells grown in tissue culture.?Results showed that the stimulation of neuronal cellular process length and branching was noted.?Moreover, the increased synaptophysin suggested that TAE-1 could stimulate synapse formation.?Increased expression of MAP2 was also observed, indicating that TAE-1 promoted the differentiation of human neurons.?In addition, targeted AChE inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes.?It was found that at increasing TAE-1concentrations, there was a corresponding decrease in the AChE activity resulting in reduced amount of oxidizable thiocholine.?The IC50 value was found to be 0.465 μM for TAE-1[1] |
分子量 | 1128.57 |
分子式 | C39H51I3N6O9 |
CAS No. | 1414469-59-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 11.29 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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TAE-1 1414469-59-2 Neuroscience AChE Beta Amyloid β-amyloid peptide inhibit TAE 1 Cholinesterase (ChE) Amyloid-β Abeta TAE1 Inhibitor inhibitor