keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
25 mg | 在庫あり | ¥ 9,500 | |||
50 mg | 在庫あり | ¥ 13,000 | |||
100 mg | 在庫あり | ¥ 18,500 | |||
500 mg | 在庫あり | ¥ 45,500 |
説明 | Tetrahydropiperine (Cosmoperine) is a natural product derived from piperine, can be used to treat convulsion, epilepsy, relieve pain, and control insects. |
ターゲット&IC50 | MOCD:25 µM, TRPV1:6.3 µM , CYP450:23 µM |
In vivo | TETRAHYDROPIPERINE is an agonist of transient receptor potential vanilloid type 1 (TRPV1; EC50 = 6.3 μM)[1]. It inhibits the cytochrome P450 (CYP) isoform CYP1A1/arylhydrocarbon hydroxylase (AHH; IC50 = 23 μM) and 7-methoxycoumarin O-demethylase (MOCD) activity (IC50 = 25 μM) in rat liver microsomes[2].Tetrahydropiperine increases skin pigmentation in a mouse model of vitiligo when 100 μl of a 175 mM solution is administered topically, an effect that can be enhanced by subsequent suberythemal ultraviolet radiation (UVR)[3]. |
動物実験 | The test compounds were PIP [5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylpiperidine], tetrahydropiperine [THP, 5-(3,4-methylenedioxyphenyl)-pentanoylpiperidine], a cyclohexyl analogue of piperine [CHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentadienoylcyclohexylamine], and reduced CHP [rCHP, 5-(3,4-methylenedioxyphenyl)-2,4-pentanoylcyclohexylamine].?Sparsely pigmented, HRA/Skh-II mice were randomized to receive topical treatment with test compounds or vehicle twice a day for five days a week, with or without ultraviolet (UV) irradiation on 3 days a week.?Treatment was either continuous or interrupted to evaluate fading and repigmentation.?Skin inflammation and pigmentation were evaluated regularly during treatment.?DOPA+ melanocytes were determined histologically at the termination of treatment[3]. |
植物由来 |
別名 | Cosmoperine |
分子量 | 289.37 |
分子式 | C17H23NO3 |
CAS No. | 23434-88-0 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 57 mg/mL (196.97 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
TETRAHYDROPIPERINE 23434-88-0 Membrane transporter/Ion channel Metabolism P450 TRP/TRPV Channel Inhibitor Cytochrome P450 AHH CYP arylhydrocarbon CYP1A1 CYPs Cosmoperine Piperine aryl pentanamide hydroxylase inhibit inhibitor