Powder: -20°C for 3 years | In solvent: -80°C for 1 year
THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively).
説明 | THPP-1 is a potent and orally bioavailable inhibitor of PDE10A(Ki of 1 nM and 1.3 nM for human and rat PDE10A, respectively). |
ターゲット&IC50 | PDE10A:1-1.3 nM |
In vivo | Consistent with rodent data, both THPP-1 and risperidone significantly attenuated the stimulant effects in SIMA when administered alone, though some differences were noted.?Combination therapy with a low dose of risperidone produced significantly more robust effects.?THPP-1 and risperidone also produced a marked reduction of wake cycle time and gamma frequency power in EEG.?However, THPP-1 differed from risperidone by reducing spectral power of lower frequencies[1]. |
分子量 | 464.9 |
分子式 | C23H21ClN6O3 |
CAS No. | 1257051-63-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 31 mg/mL (66.68 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
THPP-1 1257051-63-0 Metabolism PDE PDE10A SIMA object recognition Phosphodiesterase (PDE) Inhibitor inhibit THPP 1 THPP1 novel inhibitor