Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 22,000 | |||
5 mg | 在庫あり | ¥ 55,000 | |||
10 mg | 在庫あり | ¥ 85,500 | |||
25 mg | 在庫あり | ¥ 150,500 | |||
50 mg | 在庫あり | ¥ 211,000 | |||
100 mg | 在庫あり | ¥ 282,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 59,500 |
説明 | TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1. |
In vitro | TKIM binds to the pocket of the IM state of TREK-1, which differs from the binding of common inhibitors, which bind to channels in the inactive state.?Overall, identified an allosteric ligand-binding site and a new mechanistic inhibitor for TREK-1, suggesting that IM states of ion channels may be promising druggable targets for use in discovering allosteric modulators. |
分子量 | 371.84 |
分子式 | C18H14ClN3O2S |
CAS No. | 326921-25-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (80.68 mM)
You can also refer to dose conversion for different animals. 詳細
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TKIM 326921-25-9 Membrane transporter/Ion channel Potassium Channel Inhibitor inhibitor inhibit