Powder: -20°C for 3 years | In solvent: -80°C for 1 year
TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 18,000 | |||
25 mg | 在庫あり | ¥ 35,500 | |||
50 mg | 在庫あり | ¥ 64,000 | |||
100 mg | 在庫あり | ¥ 95,500 | |||
500 mg | 在庫あり | ¥ 216,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | TMS (2,3',4,5'-Tetramethoxystilbene) is a very selective and potent competitive inhibitor of P450 1B1 (CYP1A1). |
ターゲット&IC50 | CYP1A1:300 nM (IC50), CYP1A2:3.1 μM (IC50), CYP1B1:3 nM (Ki), CYP1B1:6 nM (IC50) |
In vitro | Twenty-four hours after incubation with the 10 μM DOX in the presence and absence of 0.5 μM TMS, approximately 1.5 × 106 cells per six-well culture plate were collected in 100 μl lysis buffer (50 mM HEPES, 0.5 M sodium chloride, 1.5 mM magnesium chloride, 1 mM EDTA, 10% glycerol (v/v), 1% Triton X-100, and 5 μl/ml of protease inhibitor cocktail). |
In vivo | Mice were administered 300 μg/kg of selective inhibitor of P450 1B1, TMS or its vehicle (dimethyl sulfoxide), i.p. every third day for the duration of the experimental period |
別名 | (E)-2,3',4,5'-tetramethoxystilbene, 2,3',4,5'-Tetramethoxystilbene |
分子量 | 300.35 |
分子式 | C18H20O4 |
CAS No. | 24144-92-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (166.47 mM)
You can also refer to dose conversion for different animals. 詳細
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TMS 24144-92-1 Metabolism P450 Cytochrome P450 (E)-2,3',4,5'-tetramethoxystilbene inhibit Inhibitor CYPs 2,3',4,5'-Tetramethoxystilbene 2,3',4,5'-tetramethoxystilbene inhibitor