Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog.
説明 | Telbivudine (NV 02B) is a Hepatitis B Virus Nucleoside Analog Reverse Transcriptase Inhibitor. The mechanism of action of telbivudine is as a Nucleoside Reverse Transcriptase Inhibitor. The chemical classification of telbivudine is Nucleoside Analog. |
In vivo | Telbivudine significantly increases the levels of tumor necrosis factor-alpha and interleukin-2 in macrophages (induced by MHV-3) as well as serum levels of interferon-gamma. It is phosphorylated by cellular thymidine kinase into an active triphosphate form, with an intracellular half-life of 14 hours. While enhancing the proliferation and secretion capabilities of T-cells, Telbivudine does not affect the cytotoxicity against infected hepatocytes. Furthermore, it inhibits the expression of programmed death ligand 1 in T-cells. Despite mutations such as N236T and A181V/A194T, Telbivudine remains active at increased magnitudes of 0.5 and 1.0 times, respectively. The differences in resistance between lamivudine and Telbivudine are due to Telbivudine's inactivity against the lamivudine-resistant HBV strain L180M/M204V/I mutation, though it remains active against the M204V single mutation. |
別名 | NV 02B, L-Thymidine, Epavudine |
分子量 | 242.23 |
分子式 | C10H14N2O5 |
CAS No. | 3424-98-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 44 mg/mL (181.6 mM)
DMSO: 50 mg/mL (206.42 mM)
Ethanol: 2 mg/mL (8.25 mM), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Telbivudine 3424-98-4 Microbiology/Virology Others HBV Reverse Transcriptase Inhibitor inhibit NV 02B Hepatitis B virus L-Thymidine Epavudine inhibitor