Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV)
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 20,000 | |||
50 mg | 在庫あり | ¥ 26,000 | |||
100 mg | 在庫あり | ¥ 35,500 | |||
500 mg | 在庫あり | ¥ 89,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV) |
In vitro | Tenofovir alafenamide fumarate (TAF) is an oral phosphonoamidate prodrug of the HIV reverse transcriptase nucleotide inhibitor tenofovir (TFV).?Overexpression of CatA or liver carboxylesterase 1 (Ces1) in HEK293T cells increased intracellular TAF hydrolysis 2- and 5-fold, respectively.?Knockdown of CatA expression with RNA interference (RNAi) in HeLa cells reduced intracellular TAF metabolism 5-fold.?Additionally, the anti-HIV activity and the rate of CatA hydrolysis showed good correlation within a large set of TFV phosphonoamidate prodrugs[1]. |
別名 | GS-7340 (hemifumarate), Tenofovir alafenamide fumarate |
分子量 | 534.51 |
分子式 | C21H29N6O5P·1/2C4H4O4 |
CAS No. | 1392275-56-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (93.54 mM)
You can also refer to dose conversion for different animals. 詳細
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Tenofovir alafenamide hemifumarate 1392275-56-7 Microbiology/Virology Proteases/Proteasome HIV Protease Reverse Transcriptase Inhibitor GS 7340 Human immunodeficiency virus Tenofovir alafenamide Fumarate GS-7340 (hemifumarate) inhibit Tenofovir alafenamide fumarate GS7340 HIV Tenofovir alafenamide GS-7340 GS-7340 hemifumarate Tenofovir alafenamide Hemifumarate inhibitor