Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM.
説明 | Thiomyristoyl is an effective and selective SIRT2 inhibitor (IC50: 28 nM). It inhibits SIRT1 (IC50: 98 μM) but no effect on SIRT3 even at 200 μM. |
ターゲット&IC50 | SIRT2:28 nM |
In vitro | In a breast cancer mouse model, Thiomyristoyl inhibits SIRT2 and tumor growth, while also reducing the levels of the c-Myc protein. The anticancer effects of Thiomyristoyl are positively correlated with the reduction of c-Myc levels. |
In vivo | Thiomyristoyl exhibits weak inhibition towards SIRT3/5/6/7. It can reduce the level of c-MYC in cancer cells in vitro, with the extent of c-MYC reduction directly proportional to the cell line’s sensitivity to Thiomyristoyl. |
細胞研究 | Human MCF-7 cells are grown in DMEM media contained 10% (vol/vol) heat-inactivated fetal bovine serum and 1% penicillin-streptomycin and treated with in the presence of 200 nM TSA for 6 hr. The acetylation level of p53 protein is determined by western blot using anti-acetyl-p53 (K382) antibody. β-actin serves as a loading control. (Only for Reference) |
分子量 | 581.85 |
分子式 | C34H51N3O3S |
CAS No. | 1429749-41-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (171.87 mM)
Chloroform: Soluble
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Thiomyristoyl 1429749-41-6 Chromatin/Epigenetic DNA Damage/DNA Repair Sirtuin Inhibitor inhibit inhibitor