Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 18,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 78,000 | |||
25 mg | 在庫あり | ¥ 130,000 | |||
50 mg | 在庫あり | ¥ 181,500 | |||
100 mg | 在庫あり | ¥ 250,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 61,500 |
説明 | Tigloylgomisin H significantly induces quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H functions as a novel monofunctional inducer that specifically upregulates phase II enzymes through the Nrf2-ARE pathway and can be used in liver cancer prevention studies. |
In vitro | In the current study, nine lignans were isolated from S. chinensis and tested for their ability to induce quinone reductase (QR) activity in Hepa1c1c7 mouse hepatocarcinoma cells. Tigloylgomisin H (TGH) and angeloylgomisin H (AGH) significantly induced QR activity and exhibited a relatively high chemoprevention index (CI) (10.80 and 4.59, respectively) as compared to control. TGH also induced QR activity in BPrc1 mouse hepatocarcinoma cells as well, which are defective in aryl hydrocarbon nuclear translocator (Arnt). In HepG2 human hepatocarcinoma cells, TGH significantly activated gene expression mediated by the antioxidant response element (ARE), a key regulatory region in the promoters of detoxification enzymes, through the nuclear accumulation of Nrf2. |
植物由来 |
分子量 | 500.58 |
分子式 | C28H36O8 |
CAS No. | 66069-55-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (99.88 mM)
You can also refer to dose conversion for different animals. 詳細
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Tigloylgomisin H 66069-55-4 Immunology/Inflammation Nrf2 inhibit Inhibitor inhibitor