Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 7,000 | |||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 26,000 | |||
25 mg | 在庫あり | ¥ 55,000 | |||
50 mg | 在庫あり | ¥ 79,000 | |||
100 mg | 在庫あり | ¥ 118,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 22,500 |
説明 | Timosaponin AIII (Timosaponin A3) induces autophagy in HeLa cells followed by apoptotic cell death (IC50: 10 μM). The Timosaponin AIII cellular response is mediated via inhibition of mTORC1 and induction of ER stress (IC50: 2.5 μM, BT474 cells; 6 μM, MDAMB231). The Timosaponin AIII pro-apoptotic response is selective for tumor cells over normal cells but autophagy is induced in both. |
ターゲット&IC50 | mTORC1(MDAMB231):6 μM, mTORC1(BT474 cells):2.5 μM |
植物由来 |
別名 | Filiferin B, AneMarsaponin A3, Timosaponin A3 |
分子量 | 740.92 |
分子式 | C39H64O13 |
CAS No. | 41059-79-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (67.48 mM)
You can also refer to dose conversion for different animals. 詳細
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Timosaponin AIII 41059-79-4 Neuroscience PI3K/Akt/mTOR signaling mTOR AChE Filiferin B Cholinesterase (ChE) inhibit Inhibitor AneMarsaponin A3 Timosaponin A3 inhibitor