Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 11,000 | |||
10 mg | 在庫あり | ¥ 15,000 | |||
25 mg | 在庫あり | お問い合わせ | |||
50 mg | 在庫あり | お問い合わせ | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 12,000 |
説明 | Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). |
ターゲット&IC50 | NMDAR:10 nM |
In vivo | Traxoprodil exhibits potent activity by effectively blocking haloperidol-induced catalepsy at doses below 1 mg/kg and counteracting NMDA-induced c-fos induction in mice at a 1 mg/kg dosage [1]. Additionally, traxoprodil demonstrates antidepressant properties in the forced swim test at doses of 20 and 40 mg/kg without affecting locomotor activity in animals [2]. Furthermore, at a concentration of 20 nM administered intracerebroventricularly (i.c.v.), traxoprodil prolongs the onset of generalized tonic-clonic seizures triggered by PTZ (70 mg/kg; i.p.). At an oral dose of 60 mg/kg, it not only delays the initiation of clonic and generalized seizures but also reduces the total duration of seizures experienced [3]. |
動物実験 | The effect of traxoprodil and SPD on PTZ-induced seizures is investigated by injecting the Adult (90-100 days-old) male Wistar rats (250-300 g) with traxoprodil (0.2, 2 or 20 nM/site), SPD (0.02, 0.2 or 2 nM/site), or with vehicle (0.9% NaCl, 1 μL) 15 min before the administration of PTZ (35 or 70 mg/kg, i.p.) [3]. The Forced swim test is done on male Albino Swiss mice (25-30 g). Traxoprodil (5, 10, 20, 40 mg/kg), imipramine and saline are administered i.p. 60 min before the test. The antidepressant activity is measured [2]. |
別名 | CP101606 |
分子量 | 327.42 |
分子式 | C20H25NO3 |
CAS No. | 134234-12-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 0.1 mg/mL (insoluble)
DMSO: 62.5 mg/mL (190.89 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Traxoprodil 134234-12-1 Membrane transporter/Ion channel Neuroscience iGluR NMDAR Ionotropic glutamate receptors CP-101606 inhibit CP 101606 Inhibitor CP101606 inhibitor