Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT)1A receptor agonist with anxiolytic activity.Befiradol hydrochloride inhibits mutant ATXN3 aggregation.
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5 mg | 在庫あり | ¥ 87,000 | |||
10 mg | 在庫あり | ¥ 127,000 | |||
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100 mg | 在庫あり | ¥ 379,000 |
説明 | Befiradol hydrochloride (NLX-112 hydrochloride) is a selective 5-hydroxytryptamine 1A (5-HT)1A receptor agonist with anxiolytic activity.Befiradol hydrochloride inhibits mutant ATXN3 aggregation. |
In vivo |
Befiradol hydrochloride (F13640 hydrochloride; NLX-112 hydrochloride) decreases the activity of dorsal raphe serotonergic neurons when administered intravenously at doses ranging from 0.2 to 18.2 μg/kg, with an effective dose (ED50) of 0.69 μg/kg, i.v. At the same dosage range, it enhances the firing rate of 80% of the medial prefrontal cortex (mPFC) pyramidal neurons, with an ED50 of 0.62 μg/kg, i.v.[1] Befiradol hydrochloride (0.04-0.63 mg/kg; i.p.) dose-dependently decreases extracellular 5-HT in the hippocampus and mPFC.[1] Befiradol hydrochloride (0.01-2.5 mg/kg; i.p.) dose-dependently increases extracellular DA in mPFC, an effect dependent on the activation of postsynaptic 5-HT1A receptors in mPFC. Local perfusion of Befiradol hydrochloride in mPFC (1-1000 μM) also increases extracellular DA in a concentration-dependent manner.[1] |
別名 | NLX-112 hydrochloride, F 13640 hydrochloride |
分子量 | 430.32 |
分子式 | C20H23Cl2F2N3O |
CAS No. | 2436760-81-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 43.03 mg/mL (100 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Befiradol hydrochloride 2436760-81-3 GPCR/G Protein Neuroscience 5-HT Receptor NLX-112 hydrochloride Befiradol Hydrochloride F-13640 Hydrochloride NLX112 Hydrochloride F 13640 Hydrochloride F 13640 hydrochloride F13640 Hydrochloride NLX 112 Hydrochloride NLX-112 Hydrochloride Inhibitor inhibitor inhibit