Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 45,500 | |||
5 mg | 在庫あり | ¥ 105,000 | |||
10 mg | 在庫あり | ¥ 153,000 | |||
50 mg | 在庫あり | ¥ 335,000 | |||
100 mg | 在庫あり | ¥ 452,500 | |||
200 mg | 在庫あり | ¥ 610,500 |
説明 | Trilaciclib hydrochloride (G1T28 hydrochloride) is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6). |
ターゲット&IC50 | CDK6-CyclinD3:4 nM, CDK4-CyclinD1:1 nM |
In vitro | Incubation with Trilaciclib hydrochloride (G1T28) for 24 hours can induce a strong G1 cell cycle arrest (time=0). Cells have re-entered the cell cycle and demonstrate cell-cycle kinetics similar to untreated control cells By 16 hours after Trilaciclib hydrochloride washout. These results demonstrate that Trilaciclib hydrochloride causes a transient, and reversible G1 arrest. A transient Trilaciclib hydrochloride-mediated G1 cell-cycle arrest in CDK4/6-sensitive cells decreases the in vitro toxicity of a variety of commonly used cytotoxic chemotherapy agents associated with myelosuppression. |
In vivo | G1T28 inhibits the phosphorylation of RB and induces an exclusive, reversible G1 arrest.n vivo, G1T28 reversibly and in a dose-dependent manner, regulates the proliferation of HSPCs.Pretreatment of mice with oral G1T28 allows for the faster recovery of CBCs following chemotherapy treatment.Likewise, oral G1T28 does not protect RB-deficient tumors from chemotherapy but adds to the antitumor effect.Although this effect was found in athymic mice that lack T lymphocytes, it is still possible that the enhanced efficacy is due to preservation of other immune cell types such as natural killer cells. |
別名 | G1T28 hydrochloride |
分子量 | 519.47 |
分子式 | C24H32Cl2N8O |
CAS No. | 1977495-97-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. 詳細
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Trilaciclib hydrochloride 1977495-97-8 Cell Cycle/Checkpoint CDK Inhibitor Cyclin dependent kinase inhibit Trilaciclib Hydrochloride Trilaciclib G1T28 Hydrochloride G1T28 G1T28 hydrochloride inhibitor