Powder: -20°C for 3 years | In solvent: -80°C for 1 year
UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM.
説明 | UAMC00039 dihydrochloride is a potent, reversible and competitive dipeptidyl peptidase II inhibitor with an IC50 of 0.48 nM. |
ターゲット&IC50 | DPP2:0.48 nM. |
キナーゼ試験 | Stability of UAMC00039 in RPMI medium or assay buffer (50 mM cacodylate buffer pH5.5) is monitored at 37 °C. The inhibitors' capacity (IC50) to inhibit DPPII is measured at different time points (up to 48 h). U937 cells are incubated with various concentrations of UAMC00039 for 15 min at 37 °C in RPMI. Cells are then ished with PBS, lysed and assayed for DPPII activity. Concentration–response and time–response curves are generated from incubations of PBMC with UAMC00039 (0.01 nM–1 μM) in RPMI at 37 °C for 1, 5, 15, 30 and 60 min. Ished cells are lysed overnight at 4 °C using 100 mM HEPES buffer pH 7.4, 10 mM EDTA, 70 μg/mL aprotinin and 1% octylglucoside. |
動物実験 | Rat: UAMC00039 is administered orally at 2 mg/kg (~5 μMol/kg in a vehicle of 2% tween 80, 10 mL/kg) on a blind basis in all in vivo assays. For each assay, a reference compound and vehicle control is analyzed concurrently. For the in vivo studies 3 to 5 animals per condition are tested. |
別名 | UAMC 00039 dihydrochloride |
分子量 | 382.76 |
分子式 | C16H26Cl3N3O |
CAS No. | 697797-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (143.69 mM)
You can also refer to dose conversion for different animals. 詳細
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UAMC00039 dihydrochloride 697797-51-6 Proteases/Proteasome Ubiquitination Proteasome UAMC00039 Dihydrochloride Inhibitor UAMC-00039 dihydrochloride UAMC 00039 UAMC-00039 Dihydrochloride UAMC00039 UAMC 00039 Dihydrochloride DPP UAMC-00039 Dipeptidyl Peptidase inhibit UAMC 00039 dihydrochloride inhibitor