Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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200 mg | 在庫あり | ¥ 7,500 | |||
250 mg | 在庫あり | ¥ 7,500 | |||
500 mg | 在庫あり | ¥ 10,500 | |||
1 g | 在庫あり | ¥ 12,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Urethane (Ethylurethane) was an antineoplastic agent .Now is used for other medicinal purposes. |
ターゲット&IC50 | AMPA receptor:34 mM(EC50), Glycine receptor:46 mM(EC50), GABAA receptor:64 mM(EC50), α4β2 nAChR:114 mM(EC50), NMDAR:70 mM(EC50) |
In vitro | urethane has a spectrum of action on ion channels, which is distinct from other anesthetics. It significantly potentiates the current responses of both GABAA and glycine receptors in a reversible and concentration-dependent manner. Conversely, urethane (10–300 mM) inhibits the responses of NMDA and AMPA receptors. Also, urethane potentiates the function of an nACh receptor and neuronal nicotinic acetylcholine, γ-aminobutyric acid A, and glycine receptors[3]. |
In vivo | Urethane, a carcinogenic substance, is favored for acute in vivo electrophysiological experiments because it induces long-lasting steady level of anesthesia with muscle relaxation and minimally affects the autonomic and cardiovascular systems[2]. Urethane affects both inhibitory and excitatory systems but the magnitude of the alterations is less than that produced by other more selective anesthetics[3]. But also, Urethane anesthesia is usually restricted to terminal (acute) experiments due to its potential long-term toxicity[1]. |
別名 | Ethyl carbamate, Ethylurethane, Carbamic acid ethyl ester |
分子量 | 89.09 |
分子式 | C3H7NO2 |
CAS No. | 51-79-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (617.35 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Urethane 51-79-6 Membrane transporter/Ion channel Microbiology/Virology Neuroscience GABA Receptor Antibacterial Parasite GluR NMDAR AChR Chloride channel inhibit carbamic narcosis mutagen acid Ethyl carbamate Inhibitor Ethylurethane Bacterial Pesticide clastogen Carbamic acid ethyl ester inhibitor