Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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10 mg | 在庫あり | ¥ 9,500 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 21,500 | |||
100 mg | 在庫あり | ¥ 32,000 | |||
500 mg | 在庫あり | ¥ 77,500 |
説明 | Picrotoxinin is a blocker of chloride channel and a noncompetitive antagonist of GABAA with an IC50 of 1.15 μM for α1β2γ2L GABAA. Picrotoxinin shows convulsant properties. |
In vitro | Picrotoxinin (1 nM-1 mM) dose-dependently inhibits the action of the GABAA receptor and inhibits etomidate, propofol, diazepam, thiopentone sodium, loreclezole and allopregnanolone with IC50s of 0.55 μM, 0.49 μM, 0.35 μM, 0.50 μM, 0.14 μM and 0.44 μM in the presence of EC5 GABA, respectively[1]. |
分子量 | 292.28 |
分子式 | C15H16O6 |
CAS No. | 17617-45-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (307.9 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Picrotoxinin 17617-45-7 Membrane transporter/Ion channel Neuroscience Chloride channel GABA Receptor Inhibitor inhibitor inhibit