Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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50 mg | 在庫あり | ¥ 10,000 | |||
100 mg | 在庫あり | ¥ 12,500 | |||
200 mg | 在庫あり | ¥ 17,500 | |||
500 mg | 在庫あり | ¥ 27,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Niflumic acid (Nifluril) is a Ca2+-activated Cl- channel blocker and an analgesic and anti-inflammatory agent used in the therapy of rheumatoid arthritis. |
In vivo | Niflumic acid suppresses calcium-activated currents on the basolateral membrane of rat pancreatic exocrine cells with an IC50 of 50 μM. It dose-dependently and reversibly activates the calcium-activated potassium (KCa) channels. Niflumic acid induces a spontaneous transient concentration-dependent inhibition of inward currents (STIC, calcium-activated chloride currents) amplitude. It inhibits calcium-activated chloride channels with a Ki of 17 mM. Additionally, Niflumic acid suppresses ICl(Ca) under the permeabilizing effect of Ca2+ on oocytes through Ca2+ ionophore A23187, suggesting the inhibition of ICl(Ca) results from direct interaction with Cl- channels, not by disruption of Ca2+ entry through voltage-dependent Ca2+ channels. Niflumic acid attenuates norepinephrine and caffeine-induced inward currents (IO(Ca)) with an IC50 of 6.6 μM, which is less effective than that on spontaneous currents. It exhibits a voltage-dependent inhibition of the amplitude of spontaneous transient currents (STIC), with IC50 values of 1.1 μM at +50 mV and 2.3 μM at -50 mV. Furthermore, Niflumic acid reduces airway hyperresponsiveness and eosinophilic infiltration, as well as inhibits IL-13 induced goblet cell hyperplasia. Following the IL-13 challenge, Niflumic acid hampers the overexpression of the MUC5AC gene (a marker of goblet cell proliferation) and levels of chemokines in bronchoalveolar lavage fluid. It also represses the activation of JAK/STAT6, AK2, and the expression of chemokines in epithelial cells. |
別名 | Nifluril, Forenol, Landruma |
分子量 | 282.22 |
分子式 | C13H9F3N2O2 |
CAS No. | 4394-00-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 52 mg/mL (184.3 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Niflumic acid 4394-00-7 Immunology/Inflammation Membrane transporter/Ion channel Metabolism Neuroscience Others COX Chloride channel Phospholipase Monocarboxylate transporter UGT Cl? Channels Inhibitor inhibit Nifluril Chloride Channel Forenol Landruma inhibitor