Powder: -20°C for 3 years | In solvent: -80°C for 1 year
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).
説明 | VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM). |
ターゲット&IC50 | mGluR5 (rat):224 nM (Ki), mGluR5 (rat):9 nM (EC50), mGluR2 (rat):1.5 μM (EC50), mGluR4 (human):154 nM (EC50), mGluR1 (rat):557 nM (EC50) |
別名 | VU 29 |
分子量 | 384.39 |
分子式 | C22H16N4O3 |
CAS No. | 890764-36-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (65.04 mM)
You can also refer to dose conversion for different animals. 詳細
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VU-29 890764-36-0 Neuroscience GluR mGluR hippocampal inhibit rat LTP potentiator allosteric Metabotropic glutamate receptors Inhibitor VU29 VU 29 LTD inhibitor