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Search Results for " hippocampal "

ターゲット

92

阻害剤

17

天然化合物

14

リコンビナントタンパク質

カタログ番号 製品名 別名 ターゲット
T20993 Memantine Others
Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...
T23515 VU-29 VU 29 GluR
VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM).
T3479 (RS)-MCPG alpha-MCPG,(±)-MCPG GluR
(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist.
T0084 Moclobemide Ro111163 MAO , Monoamine Oxidase
Moclobemide (Ro111163) is a reversible inhibitor of monoamine oxidase type A; (RIMA); (see MONOAMINE OXIDASE INHIBITORS) that has antidepressive properties.
T9776 TRPM4 inhibitor 8 TRP/TRPV Channel
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.
T23283 2-Methoxyidazoxan monohydrochloride RX 821002 hydrochloride Adrenergic Receptor
L-Albizziin (2-Methoxyidazoxan monohydrochloride) is a highly potent selective antagonist of the alpha 2r adrenergic receptor, with little or no antagonistic effect on imidazoline. It has a significantly higher affinity ...
TP2045 CH 275
Potent somatostatin receptor 1 (sst1) agonist; displays selectivity for sst1 (IC50 values are 30.9 nM, 345 nM, > 1 μM, > 10 μM and > 10μM for human sst1, sst3, sst4, sst2 and sst5 respectively). Attenuates somatostatin r...
T16288 Neuropathiazol Others
Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.
TQ0233 Traxoprodil CP101606 NMDAR , iGluR
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).
T7516 ZD7288 ICI D7288 HCN Channel
ZD7288 (ICI D7288), a selective hyperpolarization-activated cyclic nucleotide-gated channel blocker, inhibits hippocampal synaptic plasticity.
TP1380 Galanin (1-16), mouse, porcine, rat Neuropeptide Y Receptor
Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons.
T23782 Benzolamide CL-11366,W 1803,CL 11366,CL11366,W-1803 Carbonic Anhydrase
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons.
T72063 PDCD4-IN-1
PDCD4-IN-1, a PDCD4 inhibitor (Kd : 350 nM), promotes BDNF expression in hippocampal neuronal cells HT-22.
T30549 BMY-21502 Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168 Antioxidant
BMY-21502 is a potential cognitive enhancer that shows anti-hypoxia effects in the KCN-hypoxia model, delays the decay of hippocampal synaptic enhancement in vitro, and can be used to study Alzheimer's disease.
T20797 NE-100 hydrochloride NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl Sigma receptor
NE-100 hydrochloride (NE-100 HCl) is a potent and selective antagonist of σ1 (IC50 = 4.16 nM) with antipsychotic activity. NE100 HCl also suppresses ER stress-induced hippocampal cell death.
T72662 NMDAR/TRPM4-IN-2 ERK , TRP/TRPV Channel , NMDAR , iGluR
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot...
T25450L GGTI 2147 FA GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base) Others
GGTI 2147 FA, a selective GGT inhibitor, abolishes bicuculline-induced increase in dendritic spine density in hippocampal experiments and may reduce learning and memory abilities in mice.
T5618 AK-1 Sirtuin
AK-1 is a sirtuin 2 (SIRT2) inhibitor (IC50:12.5 µM).that prevents hippocampal neurodegeneration in Alzheimer's disease models and induces cell cycle arrest in colon carcinoma cells.
T27806 Lecozotan HCl SRA-333,SRA333,SRA 333,Lecozotan hydrochloride 5-HT Receptor
Lecozotan HCl (SRA-333) is a potent and selective 5-HT antagonist that significantly enhances KCl-stimulated glutamate and acetylcholine release from the hippocampal dentate gyrus and has cognitive enhancing properties. ...
T17197 UCL 2077
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker,with IC50 of 500 nM in hippocampal neurons in culture, having minima...
T10893 CS-722 Free base Others
CS-722 Free base is a synthetic central muscle relaxant with muscle relaxant activity and inhibitory effect on spinal reflex. CS-722 Free base may inhibit spontaneous inhibitory post-synaptic current and excitatory post-...
T19337 GBR 12783 dihydrochloride GBR12783 2HCl Others
GBR 12783 dihydrochloride (GBR12783 2HCl) is a specific, potent and selective dopamine uptake inhibitor. GBR 12783 dihydrochloride inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 ...
T21509 CA 074 Cysteine Protease
CA 074 is a potent inhibitor of cathepsin B with a Ki value of 2 to 5 nM.CA 074 inhibits ischemic hippocampal neuronal death in primates and attenuates retinopathy and optic neuritis in experimental autoimmune encephalom...
T3486 3-MATIDA GluR , NMDAR
3-MATIDA is an effective mGluR-1 antagonist (IC50: 6.3 μM, rat mGluR-1a). Displays ≥ 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3...
TP1895L1 KYL acetate(676657-00-4 free base) Ephrin Receptor
KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...
T38192 Unifiram Others
Unifiram is a nootropic agent.1It increases acetylcholine (ACh) release in the rat cerebral cortexin vivoand induces a long-lasting increase in the amplitude of field excitatory postsynaptic potentials (fEPSPs) in the ra...
TP1924L1 ZIP acetate(863987-12-6 free base) PKC
ZIP acetate is a novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampa...
TP1945L1 Pep2m, myristoylated acetate Pep2m, myristoylated acetate(1423381-07-0 free base) PKC
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei...
T41142 EM 163 IL Receptor , p38 MAPK , MyD88
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interacti...
T69601 ER272
ER272 is a natural PKC activator, inducing hippocampal neurogenesis.
T11839 Lesopitron dihydrochloride E4424 5-HT Receptor
T27326 FK960 FK 59960,FK-960,FK-59960,FK59960
FK962 is an enhancer of somatostatin release, which exerts cognitive-enhancing actions in rats. FK960 increases synaptic density in the hippocampal CA3 region of aged rats.
T26904 BRL 44408 Maleate Salt BRL-44408,BRL44408,BRL 44408
BRL 44408 Maleate Salt is a selective α2A-adrenoceptor antagonist with Ki value of 1.7 nM. BRL 44408 Maleate Salt increases the release of hippocampal noradrenalin following systemic administration.
T37162 8-hydroxy Efavirenz
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B...
T71977 Etiocholanedione
Etiocholanedione is a neurosteroid that inhibits glycine-induced chloride currents (IGly) in isolated rat hippocampal pyramidal neurons.
T38975 WAY-100135 dihydrochloride
WAY-100135 dihydrochloride is a potent and selective antagonist of both presynaptic and postsynaptic 5-HT 1A receptors, exhibiting an IC 50 value of 34 nM specifically at the rat hippocampal 5-HT 1A receptor. This compou...
T11371 GBR 12783 Others
GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats. GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mi...
TP1225 β-Amyloid (22-35) β-Amyloid 22-35,Amyloid β-Protein (22-35)
β-Amyloid (22-35) is a 14-aa peptide, shows aggregates and induces neurotoxicity in the hippocampal cells. Beta amyloid (22-35) is a synthetic truncated fragment of beta-amyloid peptide.
T37200 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
Biotin-amyloid-β (1-42) peptide is an affinity probe that allows amyloid-β (1-42) (Aβ42) to be detected or immobilized through interaction with the biotin ligand. It has been used to identify Aβ42 interaction partners in...
TP1230 β-Amyloid (1-42), (rat/mouse) β-Amyloid (1-42), rat,Amyloid β-peptide (1-42) (rat)
Amyloid (1-42), rat is a polypeptide composed of 42 amino acids. It is toxic to hippocampal slices and can be used in the study of alzheimer's disease.
TP1337 β-Amyloid (1-42), rat TFA
β-Amyloid (1-42), rat TFA is a 42-aa peptide, shows the effects of cytotoxicity on acute hippocampal slices, and has been used in studies of alzheimer's disease.
T37208 NAP-1
NAP-1 is a compound with anesthetic activity.1 It increases paired-pulse inhibition in the CA1 region of rat hippocampal brain slices when used at a concentration of 100 μM. NAP-1 also induces loss of righting reflex in ...
TP2007 Lei-Dab7 Lei-Dab 7
High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hipp...
T80980 Tityustoxin-Kα TsTx-Kα
Tityustoxin-Kα (TsTx-Kα) acts as an inhibitor of potassium voltage-gated channels, exhibiting a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons [1].
TP1317 Galanin (1-16), mouse, porcine, rat TFA
Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat shows high biological activity on locus coeruleus neurons.
TP1895 KYL peptide KYL
KYL peptide is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP...
T60395 Nrf2-ARE/hMAO-B/QR2 modulator 1
Nrf2-ARE/hMAO-B/QR2 modulator 1 is a new resveratrol-based multitarget-directed ligands (MTDLs) that showed a well-balanced MTDL profile: cellular activation of the NRF2-ARE pathway (CD = 9.83 μM), selective inhibition o...
TP1924 ZIP
Novel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro...
T35546 Yhhu 3792
Notch signaling pathway activator; enhances the self-renewal capability of neural stem cells (NSCs) via Notch signaling pathway activation in vitro and in vivo. Promotes the expression of Notch target genes, Hes3 and Hes...
T37661 LY 2886721 Hydrochloride
Potent and selective β-secretase (BACE) inhibitor (IC50 values are 10.2 and 20.3 nM for human BACE2 and BACE1, respectively). Displays >5,000-fold selectivity for BACE over other proteases including cathepsin D, pepsin a...

Compounds

Memantine
T20993
Synonym:
Target: Others
VU-29
T23515
Synonym: VU 29
Target: GluR
(RS)-MCPG
T3479
Synonym: alpha-MCPG,(±)-MCPG
Target: GluR
Moclobemide
T0084
Synonym: Ro111163
Target: MAO, Monoamine Oxidase
TRPM4 inhibitor 8
T9776
Synonym:
Target: TRP/TRPV Channel
2-Methoxyidazoxan monohydrochloride
T23283
Synonym: RX 821002 hydrochloride
Target: Adrenergic Receptor
CH 275
TP2045
Synonym:
Target:
Neuropathiazol
T16288
Synonym:
Target: Others
Traxoprodil
TQ0233
Synonym: CP101606
Target: NMDAR, iGluR
ZD7288
T7516
Synonym: ICI D7288
Target: HCN Channel
Galanin (1-16), mouse, porcine, rat
TP1380
Synonym:
Target: Neuropeptide Y Receptor
Benzolamide
T23782
Synonym: CL-11366,W 1803,CL 11366,CL11366,W-1803
Target: Carbonic Anhydrase
PDCD4-IN-1
T72063
Synonym:
Target:
BMY-21502
T30549
Synonym: Bms-181168,Bms 181168,Bmy 21502,Bmy21502,Bms181168
Target: Antioxidant
NE-100 hydrochloride
T20797
Synonym: NE100 Hydrochloride,NE 100 HCl,NE 100 Hydrochloride,NE-100 Hydrochloride,NE-100 HCl
Target: Sigma receptor
NMDAR/TRPM4-IN-2
T72662
Synonym:
Target: ERK, TRP/TRPV Channel, NMDAR, iGluR
GGTI 2147 FA
T25450L
Synonym: GGTI2147 FA,GGTI-2147 FA,GGTI 2147 FA(191102-87-1 Free base)
Target: Others
AK-1
T5618
Synonym:
Target: Sirtuin
Lecozotan HCl
T27806
Synonym: SRA-333,SRA333,SRA 333,Lecozotan hydrochloride
Target: 5-HT Receptor
UCL 2077
T17197
Synonym:
Target:
CS-722 Free base
T10893
Synonym:
Target: Others
GBR 12783 dihydrochloride
T19337
Synonym: GBR12783 2HCl
Target: Others
CA 074
T21509
Synonym:
Target: Cysteine Protease
3-MATIDA
T3486
Synonym:
Target: GluR, NMDAR
KYL acetate(676657-00-4 free base)
TP1895L1
Synonym:
Target: Ephrin Receptor
Unifiram
T38192
Synonym:
Target: Others
ZIP acetate(863987-12-6 free base)
TP1924L1
Synonym:
Target: PKC
Pep2m, myristoylated acetate
TP1945L1
Synonym: Pep2m, myristoylated acetate(1423381-07-0 free base)
Target: PKC
EM 163
T41142
Synonym:
Target: IL Receptor, p38 MAPK, MyD88
ER272
T69601
Synonym:
Target:
Lesopitron dihydrochloride
T11839
Synonym: E4424
Target: 5-HT Receptor
FK960
T27326
Synonym: FK 59960,FK-960,FK-59960,FK59960
Target:
BRL 44408 Maleate Salt
T26904
Synonym: BRL-44408,BRL44408,BRL 44408
Target:
8-hydroxy Efavirenz
T37162
Synonym:
Target:
Etiocholanedione
T71977
Synonym:
Target:
WAY-100135 dihydrochloride
T38975
Synonym:
Target:
GBR 12783
T11371
Synonym:
Target: Others
β-Amyloid (22-35)
TP1225
Synonym: β-Amyloid 22-35,Amyloid β-Protein (22-35)
Target:
Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)
T37200
Synonym:
Target:
β-Amyloid (1-42), (rat/mouse)
TP1230
Synonym: β-Amyloid (1-42), rat,Amyloid β-peptide (1-42) (rat)
Target:
β-Amyloid (1-42), rat TFA
TP1337
Synonym:
Target:
NAP-1
T37208
Synonym:
Target:
Lei-Dab7
TP2007
Synonym: Lei-Dab 7
Target:
Tityustoxin-Kα
T80980
Synonym: TsTx-Kα
Target:
Galanin (1-16), mouse, porcine, rat TFA
TP1317
Synonym:
Target:
KYL peptide
TP1895
Synonym: KYL
Target:
Nrf2-ARE/hMAO-B/QR2 modulator 1
T60395
Synonym:
Target:
ZIP
TP1924
Synonym:
Target:
Yhhu 3792
T35546
Synonym:
Target:
LY 2886721 Hydrochloride
T37661
Synonym:
Target:
1 2
カタログ番号 製品名 別名 ターゲット
T2210 Genipin (+)-Genipin Others , Autophagy
Genipin ((+)-Genipin), an active aglycone derived from an iridoid glycoside called geniposide, is found in the fruit of Gardenia jasminoides Ellis.
TN1038 Galgravin Apoptosis
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec...
T6S2115 Ginkgolide J BN 52024,7-beta-Hydroxyginkgolide A PDE
Ginkgolide J (BN 52024) has neuroprotective activity, it can prevent A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices.
T4912 Jatrorrhizine chloride Yatrorhizine chloride,Neprotine chloride Others , 5-HT Receptor , OCT , Antibacterial , AChE
Jatrorrhizine chloride (Neprotine chloride) is a potent and orally active uptake-2 transporter inhibitor. It exhibits a critical neuroprotective role in H2O2-induced apoptosis via inhibition of the MAPK pathway in HT22 h...
T4S2084 3'-Methoxypuerarin 3’- Methoxy Puerarin Antioxidant
3'-Methoxypuerarin shows neuron protection activity, it can protect hippocampal neurons against ischemia/reperfusion injury by inhibiting apoptosis. 3'-Methoxypuerarin(3’- Methoxy Puerarin) has antioxidant activities, it...
T2777 Ginsenoside Rg1 Sanchinoside C1,Panaxoside Rg1,Sanchinoside Rg1,Panaxoside A,Ginsenoside A2 Apoptosis , Beta Amyloid , NF-κB
Ginsenoside Rg1 (Panaxoside Rg1) is a class of steroid glycosides, and triterpene saponins found exclusively in the plant genus Panax (ginseng). It improves spatial learning and increase hippocampal synaptophysin level i...
T9143 D-Isoleucine (2R,3R)-2-Amino-3-methylpentanoic acid,(R)-Isoleucine Others
D-Isoleucine ((2R,3R)-2-Amino-3-methylpentanoic acid) is a selective activator of Asc-1 antiporter, which enhances long-term potentiation at the hippocampal CA1-CA3 via release of endogenous D-serine.
TN2347 Methylsticin Methysticin Others
Methysticin is a kavalactone isolated from the kava roots. Methylsticin (Methysticin) exhibit osteoclast formation inhibitory activity. It inhibits activation of NF-χB in lung adenocarcinoma tissue, activates Nrf2 in neu...
TN1601 Effusol Caspase
Effusol is a natural product, exhibits potent scavenging activity for DPPH and ABTS radicals(IC50 values of 79 μM and 2.73 μM, respectively). Effusol rescues CA1 LTP attenuated by corticosterone, defending the hippocampa...
T9279 Nerolidol acetate Others
Nerolidol acetate is a natural sesquiterpene with anti-cancer, anti-inflammatory, antibacterial and anti-insect activities. Nerolidol acetate can inhibit parasite activity and inhibit schistosomiasis, nematodes, malaria,...
T3826 Polygalasaponin F NF-κB , TLR , Akt , PI3K
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po...
T20493 Palmitone NSC-953,NSC953,NSC 953
In the CA3 hippocampal region, Palmitone against pentylenetetrazole-caused neuronal damage.
T83404 2,5-Dihydroxy-4-methoxyacetophenone
Compound 3, 2,5-Dihydroxy-4-methoxyacetophenone, is isolated from the 80% methanol extract of the roots of Cynanchum paniculatum Kitagawa and has been shown to inhibit glutamate-induced cytotoxicity in the hippocampal HT...
TN3351 Aflatrem GABA Receptor
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamm...
TN4580 Morachalcone A Tyrosinase
Morachalcone A displays significant tyrosinase inhibitory activity (IC50, 0.013 uM); it also exerts strong pancreatic lipase inhibition with IC 50 value of 6.2 uM. Morachalcone A exhibits neuroprotective effects on HT22-...
T81072 Suffruticosol A
Suffruticosol A, a neuroprotective compound isolated from the seeds of P. lactiflora [1], mitigates scopolamine-induced neurodegenerative cellular damage and improves hippocampal cholinergic function. Additionally, it pa...
T36448 (E)-Ajoene
(E)-Ajoene is a disulfide that has been found inA. sativumand has diverse biological activities.1,2,3,4It is active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 μg/ml, respectively) and fu...

Recombinant Proteins

カタログ番号 製品名 Species Expression System
TMPH-02214 Tomoregulin-1 Protein, Human, Recombinant (His) Human HEK293 Cells
May be a survival factor for hippocampal and mesencephalic neurons. The shedded form up-regulates cancer cell proliferation, probably by promoting ERK1/2 phosphorylation.
TMPK-00586 VSTM5 Protein, Human, Recombinant (hFc) Human HEK293 Cells
V-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced t...
TMPK-01164 VSTM5 Protein, Mouse, Recombinant (hFc) Mouse HEK293 Cells
V-set and transmembrane domain-containing protein 5 (Vstm5), a cell-adhesion-like molecule belonging to the Ig superfamily, was found in mouse brain. Knock-down of Vstm5 in cultured hippocampal neurons markedly reduced t...
TMPJ-01148 NRN1L Protein, Human, Recombinant (His) Human HEK293 Cells
Neuritin-like protein belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression ...
TMPH-01065 CCR4 Protein-VLP, Human, Recombinant (His) Human HEK293 Cells
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPH-01064 CCR4 Protein, Human, Recombinant (His & SUMO) Human E. coli
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger...
TMPJ-01112 PRKG1 Protein, Human, Recombinant (His) Human HEK293 Cells
cGMP-Dependent Protein Kinase 1 (PRKG1) belongs to the protein kinase superfamily and AGC Ser/Thr protein kinase family. PRKG1 contains one AGC-kinase C-terminal domain, two cyclic nucleotide-binding domains, and one pro...
TMPJ-01130 NPTX1 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a...
TMPY-01712 C1QB Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Complement Component 1, q subcomponent (C1q) associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulon...
TMPY-02433 APE1/APEX1 Protein, Human, Recombinant (His) Human E. coli
The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP endonuclease, DNA 3' repair diest...
TMPY-01842 Neuroligin-3/NLGN3 Protein, Human, Recombinant (His) Human HEK293 Cells
Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface p...
TMPY-02579 NRN1 Protein, Human, Recombinant (His) Human Baculovirus Insect Cells
Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervo...
TMPY-01992 Kallikrein 8/KLK8 Protein, Human, Recombinant (His) Human HEK293 Cells
Kallikrein-8, also known as Neuropsin, Serine protease 19, Serine protease TADG-14, Tumor-associated differentially expressed gene 14 protein, and KLK8 is a secreted protein that belongs to the peptidase S1 family and Ka...
TMPH-01282 ELAVL4 Protein, Human, Recombinant (His & Myc & SUMO) Human E. coli
RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs. Plays a role in the regulation of mRNA stability, alternative splicing and translation. Binds to AU-rich element (ARE) sequences in th...