Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research.
説明 | Venadaparib (NOV140101) (IDX-1197) is a potent, selective and orally active PARP inhibitor with IC50s of 1.4 nM and 1.0 nM for PARP1 and PARP2, respectively. Venadaparib is insensitive to PARP-5. Venadaparib prevents the repair of DNA single-strand breaks (SSBs) and can be used in solid tumor research. |
ターゲット&IC50 | PARP1/PARP2:1.4 nM/1.0 nM, PARP1:0.5 nM(EC50) |
In vitro | Venadaparib significantly inhibits PARP1-mediated PAR expression with an EC50?of 0.5 nM In DNA damage-induced Hela cells[1]. |
In vivo | Oral administration of Venadaparib significantly inhibits PAR(>90%) in tumor tissues until 24 hr post-dose in the germline BRCA1-mutated ovarian cancer PDX model. Venadaparib also dose-dependently inhibits potent tumor growth compared to the Olaparib treatment group[1]. |
別名 | NOV140101, IDX-1197 |
分子量 | 406.45 |
分子式 | C23H23FN4O2 |
CAS No. | 1681017-83-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (221.43 mM)
You can also refer to dose conversion for different animals. 詳細
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Venadaparib 1681017-83-3 Chromatin/Epigenetic DNA Damage/DNA Repair PARP IDX 1197 inhibit NOV140101 Inhibitor solid IDX-1197 NOV-140101 IDX1197 tumors anticancer NOV 140101 poly ADP ribose polymerase inhibitor