Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively)
説明 | Vorasidenib (PVM/MA) is an inhibitor of mutant isocitrate dehydrogenase (IDH; IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively) |
ターゲット&IC50 | IDH1 (R132H):31.9 nM , IDH2 (R140Q):31.7 nM |
In vivo | Vorsidenib reduces tumor growth in a TS603-IDH1R132H mouse xenograft model when administered at a dose of 50 mg/kg. |
別名 | PVM/MA, AG-881 |
分子量 | 414.74 |
分子式 | C14H13ClF6N6 |
CAS No. | 1644545-52-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (301.39 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Vorasidenib 1644545-52-7 Metabolism Isocitrate Dehydrogenase (IDH) PVM/MA inhibit AG 881 AG-881 Inhibitor AG881 inhibitor