Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 91,000 |
5 mg | 在庫あり | ¥ 189,000 |
10 mg | 在庫あり | ¥ 259,500 |
25 mg | 在庫あり | ¥ 388,000 |
50 mg | 在庫あり | ¥ 525,500 |
説明 | SIM-688 is a selective and orally active estrogen receptor inhibitor of NF-κB transcriptional activity (IC50 = 122 nM in HAECT-1 cells). |
ターゲット&IC50 | NF-κB:, NF-κB-luc:122 nM (in HAECT-1 cell) |
In vitro | SIM-688 displaces [3H]E2 from the ERα ligand-binding domain protein (C50=2.43 μM) and from the ERβ ligand-binding domain protein (IC50=1.5 μM)[1]. |
In vivo | SIM-688 (5 mg/kg per day, p.o.) inhibits pro-inflammatory genes including MHI, VCAM-1, RANTES, and TNF-α and induces the gene products and uterine wet weight. SIM-688 (0.3 mg/kg, p.o.) is active in the Lewis rat adjuvant-induced arthritis model [1]. |
別名 | SIM688 |
分子量 | 556.62 |
分子式 | C34H31F3N2O2 |
CAS No. | 796854-35-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (161.7 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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SIM-688 796854-35-8 Endocrinology/Hormones NF-Κb Estrogen/progestogen Receptor NF-κB SIM 688 SIM688 Inhibitor inhibitor inhibit