Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
10 mg | 在庫あり | ¥ 10,000 | |||
25 mg | 在庫あり | ¥ 14,500 | |||
50 mg | 在庫あり | ¥ 17,500 | |||
100 mg | 在庫あり | ¥ 32,000 | |||
200 mg | 在庫あり | ¥ 45,500 | |||
500 mg | 在庫あり | ¥ 80,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 9,500 |
説明 | Y15 (1,2,4,5-Benzenetetramine tetrahydrochlor) is a potent and specificsmall-molecule FAK scaffolding inhibitor that inhibits its autophosphorylation activity, blocks tumor growth. |
In vitro | Y15 inhibited viability in ?thyroid cancer cell lines in a dose-dependent manner[1]. |
細胞研究 | Apoptosis assay was done with PE Annexin V Apoptosis Detection Kit (BD) to identify apoptotic nuclei.?One hundred millimeter plates were seeded with TPC1, K1, BCPAP and TT cells at a concentration of 1 × 10^6 cells in normal growth media.?After overnight incubation, plates were treated with one of several doses of Y15 or left untreated.?After another 24 h of incubation, cells were collected with trypsin, and following centrifugation, were washed with 1× PBS.?Again, cells were centrifuged, PBS was removed and cells were resuspended in binding buffer and filtered through BD mesh tubes.?Annexin V and 7-AAD were added to the solution, vortexed and incubated for 15 minutes in the dark.?Binding buffer was added and the cells were analyzed by flow cytometry within 1 hour. |
別名 | 1,2,4,5-Benzenetetramine tetrahydrochlor, FAK Inhibitor 14 |
分子量 | 284.01 |
分子式 | C6H14Cl4N4 |
CAS No. | 4506-66-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 59 mg/mL (207.74 mM), Sonication and heating are recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Y15 4506-66-5 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors FAK PTK2 protein tyrosine kinase 2 FAK Inhibitor-14 FAK Inhibitor14 Y-15 PTK2 Focal adhesion kinase 1,2,4,5-Benzenetetramine tetrahydrochlor Y 15 Inhibitor FAK Inhibitor 14 inhibit FAK inhibitor Y15 inhibitor