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T37734 |
AMPA receptor modulator-2
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|
GluR
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AMPA receptor modulator-2 (Example 134) is a AMPA receptor modulator, with a pIC50 of 10.1 for TARPγ2 dependent AMPA receptor[1]. pIC50 = -lgIC50.
[1]. BERRY CYNTHIA G B (US), et al. AZABENZIMIDAZOLES AND THEIR USE AS AM... |
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T10307 |
AMPA receptor modulator-1
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|
iGluR
|
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AMPA receptor modulator-1 can be activated by glutamate, thereby modulating ion channels. |
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T27951 |
LY392098
|
LY-392098,LY 392098,AMPA receptor modulator-3 |
GluR
,
iGluR
|
|
LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system. |
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T16800 |
(RS)-AMPA
|
(±)-AMPA |
iGluR
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T21271 |
(S)-AMPA
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L-AMPA, S-AMPA |
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(S)-AMPA is an active isomer of AMPA and a selective agonist of AMPA. |
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T61813 |
AMPA receptor antagonist-3
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iGluR
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AMPA receptor antagonist-3 is an AMPA receptor antagonist. |
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T61068 |
AMPA receptor antagonist-2
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iGluR
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AMPA receptor antagonist-2 is an AMPA receptor antagonist. |
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T23220 |
(R)-AMPA
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Others
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inactive enantiomer of AMPA |
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T23267 |
(RS)-AMPA hydrobromide
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Others
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AMPAR agonist |
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T23085 |
NPEC-caged-(S)-AMPA
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Others
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AMPA receptor agonist |
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T60242 |
(RS)-AMPA monohydrate
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|
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(RS)-AMPA ((±)-AMPA) monohydrate, a potent and selective agonist of the excitatory neurotransmitter L-glutamic acid, is a glutamate analogue. It specifically does not interact with the binding sites of kainic acid or NMD... |
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T62127 |
AMPA-IN-1
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|
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AMPA-IN-1 is a potent inhibitor of AMPA receptors, a widely expressed receptor in the brain with a central role in the regulation of rapid excitatory synaptic transmission and synaptic plasticity. 14). |
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T79191 |
AMPA receptor modulator-5
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iGluR
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AMPA Receptor Modulator-5 (Example 217) serves as an AMPA receptor modulator, utilized in neurological disease research [1]. |
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T78971 |
AMPA receptor modulator-4
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iGluR
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AMPA Receptor Modulator-4, a 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide (BTD), serves as an orally active positive allosteric modulator of the AMPA receptors (AMPAR PAMs). This compound is capable of crossing the ... |
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T79504 |
AMPA receptor modulator-6
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iGluR
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AMPA receptor modulator-6, an AMPA receptor positive allosteric modulator (PAM), is utilized in the research of neurological diseases [1]. |
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T8779 |
HBT1
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|
GluR
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HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate... |
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T33261 |
MDK-5432
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AMPA stabilizer (R,R)-2a,MDK 5432 |
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MDK-5432, also known as AMPA stabilizer (R,R)-2a, is the most potent AMPA stabilizer. |
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T4573 |
Cyclothiazide
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GluR
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Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). |
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TQ0289 |
LY450108
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iGluR
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LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies. |
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T8458 |
CNQX disodium
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iGluR
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CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures. |
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T9133 |
Caroverine hydrochloride
|
Caroverine HCL |
GluR
,
NMDAR
,
iGluR
|
|
Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, an... |
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T7178 |
CNQX
|
FG9065 |
GluR
,
iGluR
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CNQX (FG9065) is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively) |
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T68336 |
Amrubicin HCl
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|
|
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Amrubicin, also known as SM-5887, is an anthracycline used in the treatment of lung cancer. Amrubicin intercalates into DNA and inhibits the activity of topoisomerase II, resulting in inhibition of DNA replication, and ... |
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T7706 |
LY-404187
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|
GluR
,
iGluR
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LY404187 is a positive allosteric modulator of AMPA receptors |
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T7823 |
IDRA-21
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GluR
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IDRA-21 is a positive AMPA receptor modulator. |
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T6134 |
IEM 1754 2HBr
|
IEM 1754 dihydrobromide |
GluR
|
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IEM 1754 2HBr (IEM 1754 dihydrobromide) is a selective AMPA/kainate receptor blockers for GluR1 and GluR3 with IC50 of 6 μM. |
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T1884 |
CX516
|
Ampakine CX516,BDP 12,Ampalex |
GluR
,
iGluR
|
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CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
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T8435 |
YM90K
|
YM90K hydrochloride,6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)- |
GluR
,
iGluR
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|
YM90K (6-(1H-imidazol-1-yl)-7-nitro-2,3(1H,4H)-) hydrochloride is an antagonist of AMPA receptor. |
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T34609 |
Selurampanel
|
BGG-492,BGG 492,BGG492 |
iGluR
|
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Selurampanel (BGG492) is an orally active and selective competitive AMPA glutamate receptor antagonist, a quinazoline-dione sulfonamide. selurampanel is used in the study of epilepsy, migraine and tinnitus. |
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T15820 |
Mibampator
|
LY451395 |
iGluR
|
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Mibampator (LY451395) is an effective and selective AMPA receptor potentiator. |
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T3957 |
Farampator
|
Org24448,CX-691 |
GluR
,
iGluR
|
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Farampator (CX-691) (CX-691;Org24448) is a positive modulator of AMPA receptor. |
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T31208 |
Dasolampanel
|
NGX-426,NGX 426,NGX426 |
GluR
,
iGluR
|
|
Dasolampanel (NGX-426) is an orally available ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders, including neuropathic pain and migraine. |
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T17179 |
Tulrampator
|
CX-1632,S-47445 |
iGluR
|
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Tulrampator (S-47445) is an orally bioavailable positive AMPAR with antidepressant effects. |
|
T16977 |
Talampanel
|
GYKI-53773,LY-300164 |
Apoptosis
,
GluR
|
|
Talampanel (LY-300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor antagonist with anti-seizure activity. Talampanel (IVAX) has neuroprotective effects in rodent stroke models. |
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T14281 |
Becampanel
|
AMP 397 |
Others
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T16840 |
Sampatrilat
|
UK-81252 |
Others
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Sampatrilat is an effecive and orally active vasopeptidase inhibitor of ACE and neutral endopeptidase. Sampatrilat inhibits C-domain ACE (Ki=13.8 nM) 12.4-fold more potent than that for the N-domain (Ki=171.9 nM). |
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T27123 |
Dasolampanel etibutil
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Dasolampanel etibutil is a novel selective antagonist of ionotropic glutamate receptor 5 (iGluR5). |
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T27626 |
Irampanel
|
BIIR-561CL |
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Irampanel is a neuroprotectant and anticonvulsant. |
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T34832 |
Tezampanel hydrate
|
LY293558,NGX 424,NGX424,LY-293558,NGX-424,LY 293558 |
|
|
Tezampanel is used for the treatment of migraine, neuropathic pain. |
|
T17276 |
Zonampanel
|
YM 872 |
Others
|
|
Zonampanel is a selective glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist. |
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T76814 |
Lampalizumab
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|
|
|
Lampalizumab (RG 7417), a humanized monoclonal antibody, selectively inhibits complement Factor D in the alternative complement pathway by binding to an exosite and sterically hindering Factor B's access to the active si... |
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T16964 |
SYM2206
|
SYM-2206,SYM 2206 |
Sodium Channel
,
iGluR
|
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SYM2206 is a low affinity non-competitive AMPA receptor antagonist with an IC50 value of 1.6 μM.SYM2206 exhibits anticancer activity by blocking Nav1.6-mediated sustained currents and decreasing the survival of pancreati... |
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T25853 |
NBQX Disodium
|
FG9202 disodium,NBQX 2Na |
GluR
|
|
NBQX Disodium (FG9202 disodium) is a highly selective, competitive AMPA receptor antagonist with neuroprotective and anticonvulsant activity. NBQX Disodium is a salt of NBQX. NBQX is a potent and selective AMPA/rhodosina... |
|
T19698 |
CX614
|
CX 614,CX-614 |
GluR
|
|
CX614 is a positive allosteric modulator of the AMPA receptor with respect to AMPA. |
|
T12187L |
Naspm trihydrochloride
|
1-Naphthylacetyl spermine trihydrochloride |
iGluR
|
|
|
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T62042 |
BDZ-g
|
|
iGluR
|
|
BDZ-g is a potent and selective antagonist of AMPA receptor. BDZ-g can be used for the research of various neurological disorders involving excessive activity of AMPA receptors. |
|
TP1945L1 |
Pep2m, myristoylated acetate
|
Pep2m, myristoylated acetate(1423381-07-0 free base) |
PKC
|
|
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei... |
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T16402 |
Org-26576
|
|
GluR
,
iGluR
|
|
Org-26576 is a positive allosteric modulator of the AMPA receptor. |
|
T12406 |
PEPA
|
|
iGluR
|
|
PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity. |
|
T60224 |
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)-
|
|
GluR
|
|
1H-Pyrrolo[2,1-c][1,2,4]benzothiadiazine, 2,3,3a,4-tetrahydro-, 5,5-dioxide, (3aR)- is a low activity isomer of S 18986. S 18986 is a AMPA receptor positive modulator with EC2 (Concentration that doubles the intensity of... |
