Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL).
説明 | Zoliflodacin (ETX0914) (ETX0914, AZD0914) is a new bacterial DNA gyrase/topoisomerase inhibitor. Zoliflodacin has potent in vitro antibacterial activity against Gram-positive and Gram-negative organisms, including S. aureus (MIC90: 0.25 μg/mL). |
ターゲット&IC50 | S. aureus:0.25 μg/mL (MIC90) |
In vitro | Zoliflodacin has antibacterial activity against key Gram-positive, fastidious Gram-negative (Haemophilus influenzae, Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. Zoliflodacin stabilizes and arrests the cleaved covalent complex of gyrase with double-strand broken DNA under permissive conditions and thus blocks religation of the double-strand cleaved DNA to form fused circular DNA. |
別名 | ETX0914, AZD0914 |
分子量 | 487.44 |
分子式 | C22H22FN5O7 |
CAS No. | 1620458-09-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 135 mg/mL (276.95 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Zoliflodacin 1620458-09-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology DNA gyrase Antibacterial DNA/RNA Synthesis Topoisomerase ETX0914 ETX 0914 AZD 0914 Inhibitor Bacterial inhibit AZD-0914 ETX-0914 AZD0914 inhibitor