Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 11,500 | |||
10 mg | 在庫あり | ¥ 16,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 13,000 |
ターゲット&IC50 | HDAC6:56 nM |
In vitro | In mice bearing CWR22 human prostate cancer xenografts, the combination of HPOB (300 mg/kg/day) with SAHA significantly inhibits the growth of pre-existing tumors, whereas the use of either compound alone does not exhibit a noticeable inhibitory effect. |
In vivo | In HFS cells, HPOB enhances transformation cell death induced by Etoposide, Doxorubicin, or SAHA. HPOB also augments Etoposide-induced transformation cell death in transformed cells via the apoptosis pathway. In both normal (HFS) and transformed (LNCaP, A549, and U87) cells, HPOB induces α-tubulin proteins without affecting histones, inhibiting cell growth without impacting cell viability. |
分子量 | 314.34 |
分子式 | C17H18N2O4 |
CAS No. | 1429651-50-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 36 mg/mL (114.5 mM)
DMSO: 58 mg/mL (184.5 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HPOB 1429651-50-2 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC cells anticancer Histone deacetylases tumor A549 U87 Inhibitor inhibit LNCaP CWR22 selective inhibitor