store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study solid tumors.
説明 | Uplarafenib (B-Raf IN 10) is a potent BRAF inhibitor with an IC50 in the range of 50-100 nM.B-Raf IN 10 has antitumor activity that may affect cell proliferation and differentiation did not, and can be used to study solid tumors. |
In vitro |
B-Raf IN 10 (Compound C09) (1 μM) shows more than 89% inhibition against BRAF and BRAF V600E [1]. B-Raf IN 10 shows an IC 50 between 50 and 100 nM against BRAF, and less than 50 nM against BRAF V600E.[1] B-Raf IN 10 (72 h) inhibits A375 and SK-MEL-28 cell growth but not CHL-1 and SK-MEL-31 cells [1]. Cell Viability Assay.[1] Cell Line: A375, SK-MEL-28, SK-MEL-31, and CHL-1 Concentration: Incubation Time: 72 h Result: Showed inhibition with IC 50 s less than 500 nM against A375 and SK-MEL-28 cells, and showed no inhibition against CHL-1 and SK-MEL-31. |
別名 | B-Raf IN 10 |
分子量 | 494.49 |
分子式 | C22H21F3N4O4S |
CAS No. | 1425485-87-5 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (182.00 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Uplarafenib 1425485-87-5 MAPK Raf B-Raf IN 10 Inhibitor inhibitor inhibit