Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 37,500 | |||
5 mg | 在庫あり | ¥ 95,000 | |||
10 mg | 在庫あり | ¥ 158,500 | |||
25 mg | 在庫あり | ¥ 296,000 | |||
50 mg | 在庫あり | ¥ 397,000 | |||
100 mg | 在庫あり | ¥ 535,000 |
説明 | Ifebemtinib FA (BI-853520 FA) is an orally active and potent inhibitor of adhesion patch kinase (FAK) with anticancer and antiproliferative activity for the study of ovarian and lung cancer. |
ターゲット&IC50 | FER:900 nM, FES:1040 nM, FAK:1 nM |
In vitro | The compound Ifebemtinib FA (BI-853520 FA) inhibits cancer cell growth at concentrations ranging from 0 to 3 μM for 2 hours[2]. Repression of tumor cell proliferation and invasion in 3D culture is observed with Ifebemtinib FA at concentrations from 0 to 30 μM for 4-6 days[1]. Additionally, Ifebemtinib FA represses Y397-FAK autophosphorylation at concentrations ranging from 0 to 10 μM for 24 hours, and at a concentration of 0.1 μM for 96 hours, Ifebemtinib FA demonstrates a fast and potent inhibition of FAK in this highly metastatic murine breast cancer cell line[3]. |
In vivo | The oral gavage treatment of Ifebemtinib FA (BI-853520 FA) at a dose of 50 mg/kg once daily for 0-8 weeks significantly suppresses the primary tumor growth of all three cell lines in vivo[3]. |
別名 | BI-853520 FA(1227948-82-4 Free base) |
分子量 | 634.58 |
分子式 | C29H30F4N6O6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Ifebemtinib FA Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors FAK BI853520FA(1227948824Freebase) BI-853520 FA(1227948-82-4 Free base) Inhibitor inhibitor inhibit