Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon cancer.
説明 | BRD4 Inhibitor-20 is a potent bromodomain protein 4 (BRD4) inhibitor with oral activity. BRD4 Inhibitor-20 has antiproliferative activity in cancer cell lines and is used in studies of various cancers, such as colon cancer. |
ターゲット&IC50 | BRD4 BD2:28 nM, BRD4 BD1:19 nM |
In vitro | BRD4 Inhibitor-20 has inhibitory activity for BRD4 (BD1) and BRD4 (BD2) with IC50 values of 19 nM and 28 nM, respectively. BRD4 Inhibitor-20 has anti-proliferation potency with IC50 values of 4.75 μM, 1.35 μM and 44.07 μM in HT-29, HL-60 and WI-38 cells, respectively[1]. |
In vivo | Oral BRD4 Inhibitor -20, 15mg/kg showed good oral pharmacokinetic characteristics[1]. |
分子量 | 358.41 |
分子式 | C18H18N2O4S |
CAS No. | 2490311-14-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (83.7 mM)
You can also refer to dose conversion for different animals. 詳細
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BRD4 Inhibitor-20 2490311-14-1 Chromatin/Epigenetic Epigenetic Reader Domain Inhibitor inhibitor inhibit