Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
説明 | CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12. |
ターゲット&IC50 | CDK12:52 nM (IC50), CDK7:>10 μM (IC50), CDK9:16 μM (IC50), CDK2:>100 μM (IC50) |
In vitro | In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h[1]. |
別名 | CDK12 inhibitor 2, CDK12-IN-2 |
分子量 | 532.64 |
分子式 | C32H32N6O2 |
CAS No. | 2244987-03-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (75.1 mM), Sonication and heating to 60℃ are recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CDK12-IN-2 2244987-03-7 Cell Cycle/Checkpoint CDK CDK12 inhibitor 2 Inhibitor inhibitor inhibit