Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 20,000 | |||
5 mg | 在庫あり | ¥ 53,500 | |||
10 mg | 在庫あり | ¥ 78,500 | |||
25 mg | 在庫あり | ¥ 132,500 | |||
50 mg | 在庫あり | ¥ 190,000 | |||
100 mg | 在庫あり | ¥ 259,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 49,000 |
ターゲット&IC50 | CDK19:2.6 nM (IC50), CDK8:2.3 nM (IC50) |
In vitro | CCT-251921 exhibits limited activity across a panel of 55 receptors, ion channels, and enzymes at 1 μM, as well as a panel of 279 kinases, while showing weak inhibition of CYPs. It effectively inhibits basal WNT pathway activity in human cancer cell lines with constitutive activation of WNT pathway signaling, specifically in LS174T (β-catenin mutant), SW480, and Colo205 (APC mutant) cell lines, and PA-1 human teratocarcinoma cells, which depend on WNT ligand. |
分子量 | 410.9 |
分子式 | C21H23ClN6O |
CAS No. | 1607837-31-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 15 mg/mL (36.51 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CCT-251921 1607837-31-9 Cell Cycle/Checkpoint CDK CCT251921 Cyclin dependent kinase Inhibitor inhibit CCT 251921 inhibitor