Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 31,500 | |||
5 mg | 在庫あり | ¥ 77,500 | |||
10 mg | 在庫あり | ¥ 114,500 | |||
25 mg | 在庫あり | ¥ 186,500 | |||
50 mg | 在庫あり | ¥ 259,500 | |||
100 mg | 在庫あり | ¥ 349,000 | |||
500 mg | 在庫あり | ¥ 682,000 |
説明 | Cirtuvivint (SM08502) is a potent and orally active CDC-like kinase (CLK) inhibitor that can be used to study arthritis. |
In vitro | Inhibiting serine and arginine-rich splicing factor (SRSF) phosphorylation and disrupting spliceosome activity, Cirtuvivint (SM08502) is associated with the inhibition of Wnt pathway-related gene and protein expression. Cirtuvivint induces the generation of splicing variants of Wnt pathway genes, suggesting that its mechanism for inhibiting gene expression includes effects on alternative splicing[1]. |
In vivo | Significantly inhibiting the growth of gastrointestinal tumors, orally administered Cirtuvivint (SM08502) decreases SRSF phosphorylation and Wnt pathway gene expression in xenograft mouse models[1]. |
別名 | SM08502 |
分子量 | 427.5 |
分子式 | C24H25N7O |
CAS No. | 2143917-62-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (23.39 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cirtuvivint 2143917-62-6 Cell Cycle/Checkpoint CDK SM08502 SM 08502 SM-08502 Inhibitor inhibitor inhibit