Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis.
説明 | Tubulin Inhibitor 11 is a potent, orally active agent that inhibits tubulin by targeting the Colchicine binding site. It impedes tubulin polymerization, leading to mitotic blockade and apoptosis. |
ターゲット&IC50 | Antiproliferative (DU145 cells):8 nM |
In vitro |
Swainsonine (0-40 μM ; 12 h) showed anti-proliferative activity in U251 and LN444 cells.[2] Swainsonine (30 μM ; 12 h) induced apoptosis and cell cycle arrest in G2/M phase and decreased the expression of CyclinD1 and CDK4 protein levels and increased the expression of p16 protein level.[2] Swainsonine (30 μM ; 12 h) reduces glioma cell migration and invasion.[2] |
In vivo | Swainsonine (1 mg/kg ; intraperitoneal injection ; twice daily for 10 days) and cisplatin increased the antitumor efficacy in mice.[3] |
分子量 | 409.5 |
分子式 | C22H23N3O3S |
CAS No. | 2366260-33-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (219.8 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Tubulin inhibitor 11 2366260-33-3 Apoptosis Cytoskeletal Signaling Microtubule Associated CompoundTubulininhibitor11 Inhibitor inhibitor inhibit