Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 29,500 | |||
5 mg | 在庫あり | ¥ 73,000 | |||
10 mg | 在庫あり | ¥ 121,500 | |||
25 mg | 在庫あり | ¥ 200,500 | |||
50 mg | 在庫あり | ¥ 271,000 | |||
100 mg | 在庫あり | ¥ 372,000 | |||
500 mg | 在庫あり | ¥ 741,500 |
説明 | AES-350 is a potent and orally active HDAC6 inhibitor(IC50 and a Ki of 0.0244 μM and 0.035 μM, respectively). It is also against HDAC-3, -8, and -11 in an enzymatic activity assay with IC50 values of 0.187 μM, 0.245 μM, and >1μM, respectively. AES-350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. |
ターゲット&IC50 | HDAC6:24.4 nM, HDAC11:245 nM , HDAC3:187 nM |
In vitro | AES-350 (0.25-4 μM;?18 hours) induces MV4-11 cells apoptosis in a dose-dependent manner.?The late apoptosis ratios are 8.74%, 11.7%,16.08%, 30.97%, and 38.48%, respectively at 0.25 μM-4 μM.?AES-350 has submicromolar activity (IC50=0.58±0.13 μM) against MV4-11 cells than to that of vorinostat (IC50=0.31±0.061 μM).?AES-350 is more ligand efficient and exemplifies a large therapeutic index (IC50>30 μM in noncancerous MRC-9 cells).?AES-350 is also shown to be effective in AML-3 (acute myeloid leukemia) cells (IC50=0.73 ± 0.12 μM).?An ELISA is performed using HeLa cervical cancer cell lysates, and HeLa cells highly express HDAC6 and are sensitive to AES-350.?Correspondingly, ELISA assays depicted a dose-dependent increase in HDAC6 inhibition (IC50=0.58±0.13 μM), Western blot analysis shows that AES-350 (0.1-10 μM) induces a dose-dependent increase in acetylated α-tubulin (Ac-α-tubulin), a substrate of HDAC. |
分子量 | 312.36 |
分子式 | C18H20N2O3 |
CAS No. | 847249-57-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (320.14 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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AES-350 847249-57-4 Apoptosis Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Histone deacetylases MV4-11 acute myeloid leukemia AML Inhibitor AES 350 inhibit AES350 inhibitor