Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,500 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 34,000 | |||
50 mg | 在庫あり | ¥ 53,500 | |||
100 mg | 在庫あり | ¥ 80,000 |
説明 | Cucurbit[8]uril is a highly effective and safe supramolecular compound that promotes protein heterodimerization. It selectively induces the heterodimerization of methylviologen and naphthalene functionalized proteins, demonstrating its specificity and versatility. Additionally, Cucurbit[8]uril shows exceptional oral activity and low toxicity, making it a promising candidate for various pharmaceutical and biotechnological applications. |
In vitro | Cucurbit[8]uril (0~20 μM; 48 hours; CHO-K1 cells) makes the relative cell viability dropped marginally to 86%[2].Cucurbit[8]uril indeed selectively induces the heterodimerization of MV-eYFP with Np-eCFP. Cucurbit[8]uril-induced high energy transfer between the proteins is only observed in the presence of all three supramolecular components, allowing the formation of the ternary complex. In the presence of Cucurbit[8]uril, the unspecific protein assembly induced by the methylviologen is inhibited. The ternary system of Cucurbit[8]uril with methylviologen (MV) and naphthalene (NP) can also be successfully used for the formation of selective protein heterodimers of more hydrophobic proteins. The presence of Cucurbit[8]uril as a host molecule is required to prevent MV induced unspecific dimerization with hydrophobic protein surfaces[1]. |
In vivo | Cucurbit[8]uril exhibits minimal toxicity when administered either intravenously or orally in mice, as demonstrated by in vivo studies[2]. |
分子量 | 1329.1 |
分子式 | C48H48N32O16 |
CAS No. | 259886-51-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Cucurbit[8]uril 259886-51-6 Others inhibit methylviologen heterodimerization naphthalene potent supramolecular orally Inhibitor low-toxicity inhibitor