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カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T6617 | Optovin | TRP/TRPV Channel | |
Optovin is a TRPA1 activator, which is reversibly photoactivated. | |||
T9787 | Suvn-911 | AChR | |
suvn-911 is a potent and selective antagonist of neuronal nicotinic acetylcholine α4β2 receptor (Ki = 1.5 nM) with antidepressant activity. | |||
T9357 | Ro 5212773 | Epptb | Others |
Ro 5212773 (Epptb) is a selective TAAR1 antagonist. | |||
T5447 | Anle138b | Beta Amyloid , Others | |
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease | |||
T7899 | VU0810464 | Potassium Channel | |
VU0810464 is a non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. | |||
T2164 | Wiskostatin | Others | |
Wiskostatin is a selective inhibitor of N-WASP, a ubiquitously expressed member of the Wiskott-Aldrich Syndrome protein (WASp) family that regulates actin polymerization. | |||
T5850 | Benzamil | Benzamil (hydrochloride) | Na+/Ca2+ Exchanger , Sodium Channel |
Benzamil is an epithelial sodium channel (ENaC) blocker that inhibits sodium transport from (IC50 = 4 nM) and binds to (Kd = 5 nM) bovine kidney cortex membrane vesicles. | |||
T11095L | DREADD agonist 21 | 5-HT Receptor , Adrenergic Receptor , AChR , Histamine Receptor | |
DREADD agonist 21 is a potent agonist of human muscarinic acetylcholine M3 receptors (EC50=1.7 nM). | |||
T21902 | ML351 | Lipoxygenase | |
ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM). | |||
T15286 | Flindokalner | BMS-204352 | Potassium Channel |
Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p... | |||
T2022 | CZC-54252 | CZC54252,CZC 54252 | LRRK2 |
CZC-54252 is a potent inhibitor of LRRK2. | |||
T3478 | Ro 67-7476 | GluR | |
Ro 67-7476 is a positive allosteric modulator of mGlu1 receptors. No activity at human mGlu1 receptors. Potentiates glutamate-induced calcium release with EC 50 of 60.1 nM. | |||
T6697 | TCID | UCH-L3 Inhibitor | DUB |
TCID (UCH-L3 Inhibitor)(IC50=0.6 μM) is a DUB inhibitor of ubiquitin C-terminal hydrolase L3. It has the 125-fold selectivity to L1. | |||
T39202 | CZC-54252 hydrochloride | LRRK2 | |
CZC-54252 hydrochloride is a selective inhibitor of LRRK2 with IC50s of 1.85 nM and 1.28 nM for wild-type and G2019S LRRK2. CZC-54252 hydrochloride has a neuroprotective activity and attenuates G2019S LRRK2-induced human... | |||
T4612 | NS309 | EGFR , Potassium Channel , HER | |
NS309 is a nonselective activator of small- and intermediate-conductance Ca2+-activated K+ (SK/KCa2 and IK/KCa3.1) channels (EC50s range from 0.12-1.2 µM for SK channels and 10-90 nM for IK channels). It can also activat... | |||
T5827 | BI-6C9 | Apoptosis , Others , Mitochondrial Metabolism | |
BI-6C9 is an inhibitor of tBid (Kd = 20 µM).BI-6c9 prevented MOMP and mitochondrial fission, and protected the cells from cell death. | |||
T0946 | Mepivacaine hydrochloride | Mepivacaine HCl | Sodium Channel |
Mepivacaine hydrochloride (Mepivacaine HCl) is the hydrochloride salt form of mepivacaine, an amide derivative with local anesthetic properties. | |||
T19659 | Annaosanchun | YC6,YC-6,YC 6 | Others , AMPK |
Annaosanchun (YC-6) is potentially for the treatment of acute ischemic stroke (AIS). | |||
T60080 | TMPH | 2,2,6,6-Tetramethylpiperidin-4-yl heptanoate | AChR |
TMPH is an inhibitor of nAChR and inhibits nAChRs lacking α5, α6, or β3 subunits. TMPH can be used in studies about nAChR dysfunction or neurological disorders. | |||
T0386L | Ropivacaine | LEA-103 HCl | Potassium Channel , Sodium Channel |
Ropivacaine (LEA-103 HCl) is a local anaesthetic drug belonging to the amino amide group. | |||
T19062 | Sulforhodamine 101 | SR101 | Others |
Sulforhodamine 101 (SR101) is a red fluorescent dye. | |||
T0386 | Ropivacaine hydrochloride | Ropivacaine monohydrochloride | Potassium Channel , Sodium Channel |
Ropivacaine hydrochloride (Ropivacaine monohydrochloride) is the hydrochloride salt of ropivacaine, a local anesthetic of the amide type with analgesic activity. | |||
T7002 | Trihexyphenidyl hydrochloride | Triesifenidile,Benzhexol hydrochloride,Tremin,Artane hydrochloride | AChR |
Trihexyphenidyl hydrochloride (Benzhexol hydrochloride) is an antiparkinsonian agent of the antimuscarinic class. | |||
T6488 | Epinastine hydrochloride | Alesion,Epinastine HCl,WAL-801CL HCl,Elestat | 5-HT Receptor , Histamine Receptor |
Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. | |||
T1567 | Olanzapine | LY170053 | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , AChR |
Olanzapine (LY170053) is an atypical antipsychotic that is used currently in the treatment of schizophrenia and bipolar illness. | |||
T11571 | HLY78 | 4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine | Wnt/beta-catenin |
HLY78 (4-Ethyl-5-methyl-5,6-dihydro-[1,3]dioxolo[4,5-j]phenanthridine) targets the DIX domain of Axin, is an activator of the Wnt/β-catenin signaling pathway and can enhance Axin-LRP6 binding to promote Wnt signaling. | |||
T4358 | Vosilasarm | Testolone,RAD140 | Androgen Receptor |
RAD140 is an investigational selective androgen receptor modulator (SARM) for the treatment of conditions such as muscle wasting and breast cancer. | |||
T0499 | Oxybenzone | KAHSCREEN BZ-3,Benzophenone 3,Eusolex 4360,Escalol 567 | Apoptosis , Retinoid Receptor , Autophagy |
Oxybenzone (Eusolex 4360) is an organic compound used in sunscreens. It is a derivative of benzophenone. | |||
T0031L | Ziprasidone hydrochloride | CP-88059 hydrochloride,CP-88059,Ziprasidone HCl | Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Norepinephrine , Histamine Receptor |
Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity. | |||
T6645 | Ropivacaine hydrochloride monohydrate | Ropivacaine HCl,Ropivacaine HCl monohydrate,LEA 103,LEA-103 HCl | Potassium Channel , Sodium Channel |
Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction in nerve fibres through inhibiting sodium ion influx reversibly. | |||
T23446 | TCS 2210 | Others | |
TCS 2210 is an inducer of neuronal differentiation in mesenchymal stem cells and increases the neuronal markers β-III tubulin expression and neuron-specific enolase expression. | |||
T25450 | GGTI 2147 | GGTI2147,Geranylgeranyl transferase inhibitor-2147,GGTI-2147 | NF-κB , Rho |
GGTI 2147 decreased Rac1 activity, down-regulated p65 expression, and ameliorated OGD/R-induced neuronal apoptosis. | |||
T7474 | 7-Nitroindazole | NOS | |
7-Nitroindazole is a non-selective inhibitor of NOS isoforms in vitro for neuronal nitric oxide synthase showing a 10-fold selectivity for neuronal NOS. | |||
T16288 | Neuropathiazol | Others | |
Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells. | |||
T12738L1 | Rivanicline 2HCl | Rivanicline 2HCl(15585-43-0 Free base) | AChR |
Rivanicline 2HCl is a selective neuronal nicotinic receptor inhibitor with a high affinity for the α4β2 subtype. | |||
T14912 | CD3254 | Retinoid Receptor | |
CD3254 is a selective and potent retinoid X receptor-like (RXR) agonist that inhibits neuronal cell death with OGD/reoxygenation. | |||
T12017 | Methyllycaconitine citrate | MLA | AChR |
Methyllycaconitine citrate (MLA) is an α7 neuronal nicotinic acetylcholine receptor (α7nAChR) antagonist that crosses the blood-brain barrier. | |||
T19892 | BSBM7 | Beta Amyloid | |
BSBM7 is an inhibitor of Aβ aggregation and neuronal toxicity. | |||
T16287 | Neurodazine | DNA Methyltransferase | |
Neurodazine is a neural inducer that promotes the differentiation of pluripotent cells into neuronal cells.Neurodazine promotes differentiation by activating Wnt and Shh signaling. | |||
T5170 | KHS101 hydrochloride | FGFR , Microtubule Associated | |
KHS101 is a TACC3 inhibitor and can selectively induce a neuronal differentiation phenotype. | |||
T15196 | EC23 | BASF-46928,AGN 190205 | Others |
EC23 (AGN 190205) is a stable synthetic retinoid analogue. It is also induces neuronal differentiation. | |||
T2285 | Encenicline hydrochloride | EVP-6124 (hydrochloride),EVP-6124 hydrochloride | AChR |
Encenicline hydrochloride (EVP-6124 hydrochloride) is a new-type partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). | |||
T0222 | Proparacaine hydrochloride | Proparacaine HCl,Proxymetacaine Hydrochloride | Apoptosis , Sodium Channel |
Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. Proparacaine hydrochloride (Proparacaine HCl) stabilizes the neuronal membrane by bindi... | |||
T2166 | TWS119 | GSK-3 , Autophagy | |
TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation | |||
T1880 | P7C3 | Others | |
The P7C3 class of neuroprotective aminopropyl carbazoles has been shown to block neuronal cell death in models of neurodegeneration. We now show that P7C3 molecules additionally preserve axonal integrity after injury, be... | |||
T10813 | Cilobradine hydrochloride | DK-AH 269 | HCN Channel |
Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels. | |||
T8725 | A 582941 HCl (848591-90-2(free base)) | AChR | |
A-582941 is a alpha7 neuronal nicotinic receptor agonist with broad spectrum cognition-enhancing properties | |||
T28544 | RL648_81 | Potassium Channel | |
RL648_81 is a selective activator of KCNQ2/3 channels (EC50 = 190 nM). RL648_81 can be used in studies about neuronal hyperexcitability neurologic disorders. | |||
T26854 | BMS641 | BMS-641,BMS-209641,BMS 641 | Retinoid Receptor |
BMS641 (BMS-209641) is a selective and potent RARβ agonist.BMS641 has a high affinity for RARβ and synergistically activates RARβ and RARgamma to induce cellular maturation into specialized neuronal subtypes. | |||
T72063 | PDCD4-IN-1 | ||
PDCD4-IN-1, a PDCD4 inhibitor (Kd : 350 nM), promotes BDNF expression in hippocampal neuronal cells HT-22. |
カタログ番号 | 製品名 | 別名 | ターゲット |
---|---|---|---|
T9076 | Spinosad | Others | |
Spinosad is a naturally-occurring insecticide found in the the soil bacterium S. spinosa. It is a mixture of the macrocyclic lactones spinosyn A and spinosyn D, which act as agonists of insect nicotinic acetylcholinester... | |||
T0853 | Adenosine | D-Adenosine,Adenine riboside | Apoptosis , Nucleoside Antimetabolite/Analog , Endogenous Metabolite , Autophagy |
Adenosine (D-Adenosine) is a ribonucleoside comprised of adenine bound to ribose, with vasodilatory, antiarrhythmic and analgesic activities. | |||
TN6714 | Geranylgeraniol | FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,CJ-24095 | Apoptosis |
Geranylgeraniol (FT0626663) is an isoprenoid found in fruits, vegetables, and grains, including rice. Geranylgeraniol (FT0626663) inhibits growth and induces apoptosis of various tumor cells. Geranylgeraniol (FT0626663) ... | |||
TN6924 | Anhydrosafflor yellow B | (2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]cyclohexa-1,4-dien-1,AHSYB | Others |
Anhydrosafflor yellow B ((2S,3S)-6,7-dihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-2-[(1S,2R,3R)-1,2,3,4-tetrahydroxybutyl]-3-{2,3,4-trihydroxy-5-[(2E)-3-(4-hydroxyphenyl)prop-2-enoyl]-6-oxo-3-[(2R,3R,4S,5S,6R)-3,4,... | |||
TN1038 | Galgravin | Apoptosis | |
Galgravin has anti-inflammatory, and neuroprotective effects, it can promote neuronal survival and neurite outgrowth, protect hippocampal neurons against amyloid beta peptide (Abeta25-35)-induced cytotoxicity, and protec... | |||
T13923 | Thiamine nitrate | Vitamin B1 nitrate | Others |
Thiamine nitrate (Vitamin B1 nitrate) is an essential vitamin, and can enhance normal neuronal actives. | |||
T3931 | Isobavachin | Others | |
Isobavachin can facilitate mouse ES cells differentiating into neuronal cells. | |||
T6S0659 | Rhynchophylline | Rhynchophyllin,Rhyncophylline,Mitrinermine,Mitrinermin | Calcium Channel , NF-κB |
1. Rhynchophylline (Mitrinermine) can protect against ischemic damage, probably via regulating the Akt/mTOR pathway. 2. Rhynchophylline can protect against glutamate-induced neuronal death, can inhibit MA impairment in c... | |||
T5287 | N-Acetyl-L-aspartic acid | AC-ASP-OH,N-Acetylaspartic acid | Others , Endogenous Metabolite |
N-Acetyl-L-aspartic acid (AC-ASP-OH) is a derivative of aspartic acid. It is the second most concentrated molecule in the brain after the amino acid glutamate. It is synthesized in neurons from the amino acid aspartate a... | |||
T0268 | Lobeline hydrochloride | α-Lobeline hydrochloride,L-Lobeline hydrochloride | AChR |
Lobeline hydrochloride (α-Lobeline hydrochloride) is a nicotinic receptor agonist, acting as an effective antagonist at both α4β2 and α3β2 neuronal nicotinic receptor subtypes. | |||
T5S0733 | Picroside III | Others | |
Picroside III, an iridoid glucoside found in the root of Picrorhiza scrophulariiflora Pennell (Scrophulariaceae), and its subtype Picroside II has been demonstrated to reduce apoptosis in neuronal cells and other cell ty... | |||
T64353 | 4-tert-Octylphenol | Endogenous Metabolite | |
4-tert-Octylphenol, an endocrine-disrupting chemical with estrogenic properties, notably induces apoptosis in offspring mouse brain neuronal progenitor cells. This compound decreases levels of bromodeoxyuridine (BrdU), m... | |||
T6S0654 | Isocorynoxeine | 7-Isocorynoxeine | 5-HT Receptor |
1. Isocorynoxeine (7-Isocorynoxeine) shows the effects of lowering blood pressure, vasodilatation, and protection against ischemia-induced neuronal damage. 2. Isocorynoxeine exhibits a significant neuroprotective effect ... | |||
T8852 | Tubuloside B | Apoptosis , Others | |
The neuroprotective effect of tubuloside B, one of the phenylethanoids isolated from the stems of Cistanche salsa, on tumor necrosis factor-alpha (TNFalpha)-induced apoptosis in SH-SY5Y neuronal cells. | |||
T0086 | Galanthamine hydrobromide | Galantamine hydrobromide,Galanthamine HBr | AChR , AChE |
Galanthamine hydrobromide (Galantamine hydrobromide), a long-acting and centrally active AChE inhibitor (IC50:410 nM), is an allosteric potentiator at neuronal nicotinic ACh receptors. | |||
T3861 | Isobavachalcone | Corylifolinin,Isobacachalcone | Apoptosis , Others , Reactive Oxygen Species , Akt , Autophagy |
Isobavachalcone (Corylifolinin) is a chalcone constituent of Angelica keiskei, has potent anti-inflammatory activity, possible can ameliorate neuronal injury in brain diseases associated with inflammation. | |||
TN1957 | Mulberrofuran Q | MulberrofuranQ | |
Mulberrofuran Q is an active compound that inhibits the formation of 12-hydroxy-5,8,10-heptadecatrienoic acid (HHT) and thromboxane B2 (cyclooxygenase product) , which protects neuronal cells from hypoxia-glycorrhoea-def... | |||
T2S2172 | Nerolidol | (±)-Nerolidol,Peruviol | Others , Endogenous Metabolite , Antibacterial , Parasite , Antifungal |
Nerolidol (Peruviol) shows sedative effects in animals, oxidative process plays a crucial role on neuronal pathological consequence. Nerolidol is mainly related to ROS and DNA single strand breaks generated by the presen... | |||
T3902 | Atractylenolide III | ICodonolactone,8β-Hydroxyasterolide | Apoptosis |
Atractylenolide III (ICodonolactone) may have therapeutic potential in treating homocysteine-mediated cognitive impairment and neuronal injury. Atractylenolide III is a potential candidate for the treatment of human lung... | |||
T2O2741 | Thiamine monochloride | Thiamine chloride,Vitamin B1 | Others , Antioxidant , Endogenous Metabolite , Antibacterial |
Thiamine monochloride (Vitamin B1) is an essential vitamin with erythropoietic, glucose-regulatory, antioxidant, and mood-regulatory properties.Thiamine monochloride inhibits lead-induced lipid peroxidation, thereby prev... | |||
T3S0645 | N-trans-Feruloyltyramine | Feruloyltyramine,N-Feruloyltyramine,Moupinamide | Others , COX |
1. N-trans-Feruloyltyramine (Feruloyltyramine)(NTF) has hepatoprotective effect. 2. NTF has antioxidative activity against Aβ(1-42)-induced neuronal death. 3. NTF is likely to inhibit COX enzymes, thereby suppressing P-s... | |||
T3S1068 | Oxyresveratrol | trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,Tetrahydroxystilbene | Tyrosinase , Autophagy , HSV |
1. Oxyresveratro can inhibit tyrosinase activity. 2. Oxyresveratro is useful to trauma models, as toxicity to glia could be beneficial by inhibiting reactive gliosis. 3. Oxyresveratrol (trans-Oxyresveratrol) has antioxid... | |||
T26288 | Clovamide | trans-Clovamide,N-trans-Caffeoy-L-dopa | Apoptosis , Influenza Virus , ROS , Antibacterial |
Trans-Clovamide (trans-Clovamide) is a naturally occurring caffeoyl conjugate identified in the antioxidant polyphenolic fraction of cocoa (T. cacao L.) Trans-Clovamide is a potent antioxidantand that has shown neuroprot... | |||
TN4368 | Kaempferol-3,7-di-O-β-glucoside | Kaempferol 3,7-di-O-glucoside | Glucosidase , Amylase |
Kaempferol-3,7-di-O-β-glucoside (Kaempferol 3,7-diglucoside) is a flavonol from Morettia philaena, It can inhibit α-amylase, α-glucosidase and Acetylcholinesterase. Kaempferol-3, 7-di-o-β-Glucoside has neuroprotective ac... | |||
T6S1740 | Nardosinone | Others | |
1. Nardosinone has inhibitory effect on Ang II-induced hypertrophy in H9c2 cells, might be mediated by targeting PI3K/Akt and MEK/ERK signaling pathways. 2. Nardosinone could protect against the neuronal injury exposed t... | |||
T4956 | Tetrahydroxystilbene-2-O-β-D-glucoside | tetrahydroxyl diphenylethylene-2-o-gluco,EH-201 | Others |
Tetrahydroxystilbene-2-O-β-D-glucoside (EH-201) is a low MW inducer of erythropoietin. Tetrahydroxystilbene-2-O-β-D-glucoside induces expression of erythropoietin, PPAR-γ coactivator 1α (PGC-1α) and haemoglobin in astroc... | |||
T4S0145 | Corylifol A | Corylinin | hCE , STAT , UGT |
1. Corylifol A (Corylinin) displays cytotoxic activity against HepG2 and Hep3B hepatocellular carcinoma cell lines, with IC50 values of 4.6 and 13.5 ug/ml, respectively. 2. Corylifol A and Biochanin A can be the potentia... | |||
TN1831 | Macranthoside A | Kalopanaxsaponin H | Antioxidant |
Macranthoside A (Kalopanaxsaponin H) is a triterpenoid glycoside extracted from rehmannia and belongs to the iridoterpenoid synthesis. Macranthoside A has anti-inflammatory, antioxidant, antibacterial and neuroprotective... | |||
T37280 | PE(18:1(9Z)/0:0) | Endogenous Metabolite | |
PE(18:1(9Z)/0:0) is a naturally-occurring lysophospholipid and an analog of plasmalogen lysophosphatidylethanolamine. PE(18:1(9Z)/0:0) induces transient increases in intracellular calcium in PC12 rat neuronal cells in a ... | |||
T3826 | Polygalasaponin F | NF-κB , TLR , Akt , PI3K | |
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and reduce the expression of inducible nitric oxide synthases. Po... | |||
T20493 | Palmitone | NSC-953,NSC953,NSC 953 | |
In the CA3 hippocampal region, Palmitone against pentylenetetrazole-caused neuronal damage. | |||
T9454 | 4-Hydroxyestrone | Estrogen Receptor/ERR , Endogenous Metabolite | |
4-Hydroxyestrone, an endogenous estrogen metabolite, can strongly protect neuronal cells against oxidative damage. | |||
TN1581 | Dihydroguaiaretic acid | COX , DNA/RNA Synthesis | |
Dihydroguaiaretic acid has antioxidative activity, can significantly protect primary cultured neuronal cells against glutamate-induced oxidative stress. | |||
T4954L | Smilagenin | PYM50028,Cogane,AI3-44895,PYM 50028 | |
Smilagenin is an orally active inducer of nonpeptide neurotrophic factor. It also prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons, and by MPTP in a mouse model of Parkinson's disease. | |||
T11041 | Dihydro-β-erythroidine hydrobromide | DHβE hydrobromide | Others |
Dihydro-β-erythroidine hydrobromide(DHβE) is a potent, oral active and competitive antagonist of neuronal nicotinic acetylcholine receptors (nAChRs). Dihydro-β-carotene hydrobromide showed selectivity to α4β4 and α4β2nAC... | |||
TN4435 | Licopyranocoumarin | P450 , ROS , JNK | |
Licopyranocoumarin could as a potent neuroprotective drug via markedly blocked MPP+-induced neuronal PC12D cell death and disappearance of mitochondrial membrane potential, which were mediated by JNK. | |||
TN1653 | Fustin | ERK , Beta Amyloid , AChR | |
Fustin is the phytogenic flavanol component of the plant Rhus verniciflua Stokes. Fustin shows protective effects on 6-hydroxydopamine-induced neuronal cell death. | |||
T5143 | Corynoxine hydrochloride(6877-32-3(free base)) | Autophagy | |
Corynoxine hydrochloride is a natural oxindole alkaloid and induces autophagy in different neuronal cell lines, including N2a and SHSY-5Y cells. | |||
T81814 | Methyl Ganoderic acid B | ||
Methyl Ganoderic acid B, a triterpenoid isolated from Ganoderma lucidum, exhibits neuronal survival-promoting effects similar to nerve growth factor (NGF-like) [1]. | |||
T75469 | Neoechinulin C | ||
Neoechinulin C, an alkaloid in the echinulin class of indolediketopiperazine, shields neuronal cells from paraquat-induced damage in a Parkinson’s disease model [1]. | |||
TN2149 | Reynosin | BCL , Others , TNF | |
Reynosin has hepatoprotective, and anti-inflammatory effects, it has protective effect against dopamine-induced neuronal cell death, which may be due to the reciprocal up-regulation of E6-associated protein and down-regu... | |||
T82058 | Inubritannolide A | ||
Inubritannolide A exhibits moderate to robust neuroprotective effects across various neuronal cell types against inducers such as H2O2, 6-hydroxydopamine (6-OHDA), and lipopolysaccharide (LPS). | |||
TN3351 | Aflatrem | GABA Receptor | |
Aflatrem is a tremorgenic mycotoxin with acute neurotoxic effects, a single low dose of aflatrem is able to induce degeneration of neuronal processes in hippocampal neurotransmitter systems. Aflatrem potentiates the gamm... | |||
T14011 | 2-Arachidonoylglycerol | Cannabinoid Receptor , Endogenous Metabolite | |
T79998 | Celosin K | Apoptosis | |
Celosin K (compound 8), isolated from Semen Celosiae seeds, effectively inhibits t-BHP-induced neuronal injury. It mitigates oxidative stress, prevents apoptosis, and promotes autophagy [1]. | |||
T4S0823 | Astragaloside | Others | |
Astragaloside may protect against brain contusion and neuronal apoptosis after TBI by attenuating microglia activation in male rats. Astragalosides-induced apoptosis in NB4 cells may be associated with down-regulation of... | |||
T82339 | Gangliotetraose | Gg4 | |
Gangliotetraose (Gg4), a tetrasccharide, predominantly comprises GM1 and its sialylated derivatives, which play a crucial role in modulating nuclear Ca2+ efflux and maintaining lower nuclear Ca2+ levels in differentiated... | |||
TN3410 | Anatabine | Beta Amyloid , IL Receptor , TNF , NF-κB , BACE , COX , STAT | |
Anatabine shows anti-inflammatory activity in vitro and in vivo, which is mediated in part via an inhibition of STAT3 phosphorylation.Anatabine has anti-Alzheimer's disease effects, it inhibits BACE-1 transcription and r... | |||
TN3741 | Cyclocurcumin | TNF , ROS | |
Cyclocurcumin, a curcumin derivative, exhibits anticancer, anti-inflammatory, and immune-modulating abilities and is a potential compound for the treatment of rheumatoid arthritis as predicted by the MM-PBSA method. It m... | |||
TN3806 | Dehydroglyasperin C | ERK , IκB/IKK , p38 MAPK , TNF , NF-κB , Akt , COX , PI3K , NADPH , DNA/RNA Synthesis , Nrf2 , JNK , Autophagy | |
Dehydroglyasperin C is a potent NAD(P)H:oxidoquinone reductase (NQO1) and phase 2 enzyme inducer. Dehydroglyasperin C possesses potent antioxidant, cancer chemopreventive, and neuroprotective activities, it has protectiv... | |||
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カタログ番号 | 製品名 | Species | Expression System |
---|---|---|---|
TMPY-02646 | NSE/ENO2 Protein, Human, Recombinant (His) | Human | E. coli |
The combination of silencing ENO2 and 2-deoxyglucose (2-DG) synergistically inhibited leukemia cell survival. ENO2 may be a biological marker for monitoring chemotherapeutic efficacy and relapse in ALL. Reduced ENO2 expr... | |||
TMPY-01143 | N Cadherin Protein, Human, Recombinant (His) | Human | HEK293 Cells |
N Cadherin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 78.5 kDa and the accession number is A0A024RC42. | |||
TMPY-05000 | NPTXR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
NPTXR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.8 kDa and the accession number is O95502. | |||
TMPY-04856 | LRRTM2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
LRRTM2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 71.2 kDa and the accession number is O43300. | |||
TMPY-01655 | LRRTM4 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LRRTM4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.6 kDa and the accession number is Q86VH4-1. | |||
TMPY-04823 | LRRTM2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
LRRTM2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46 kDa and the accession number is O43300. | |||
TMPJ-01130 | NPTX1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Neuronal Pentraxin (NPTX1, NP1) is a secreted glycoprotein within the Pentraxin family. NPTX1 is co‑expressed and forms heteromultimers with the related secreted protein, NPTX2/NARP, NPTXR (Neuronal Pentraxin Receptor) a... | |||
TMPY-00554 | CHRNB3 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec... | |||
TMPY-04195 | CHRNB3 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Cholinergic nicotinic receptor (CHRN) gene family has been known to mediate the highly additive effects of nicotine in the body, and implicated nicotine dependence (ND) and related phenotypes. Cigarette smoking is protec... | |||
TMPY-04321 | CHRNA5 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in ... | |||
TMPY-00068 | LRRTM4 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
LRRTM4 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.4 kDa and the accession number is Q80XG9-2. | |||
TMPY-01800 | NEGR1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
NEGR1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 33 kDa and the accession number is Q80Z24. | |||
TMPK-01030 | LRRN1 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction be... | |||
TMPH-01763 | CHRNB2 Protein, Human, Recombinant (His & V5) | Human | E. coli |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodiun ions. CHRNB... | |||
TMPY-01913 | NEGR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
NEGR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.9 kDa and the accession number is Q7Z3B1-1. | |||
TMPJ-00587 | NRCAM Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily.... | |||
TMPH-01762 | CHRNA3 Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. CHRNA3 Protein, Human, Recombi... | |||
TMPY-02491 | LRRN3 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Leucine-rich repeat neuronal protein 3, also known as neuronal leucine-rich repeat protein 3 (NLRR-3), is a member of the leucine-rich (LRR) family whose members have significant functions in neural development. Leucine-... | |||
TMPY-03703 | N Cadherin Protein, Mouse, Recombinant | Mouse | HEK293 Cells |
N Cadherin Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 29 kDa and the accession number is P15116. | |||
TMPY-03692 | N Cadherin Protein, Human, Recombinant (His & hFc) | Human | HEK293 Cells |
N Cadherin Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 35.2 kDa and the accession number is A0A024RC42. | |||
TMPH-02641 | ECEL1 Protein, Mouse, Recombinant (His & Myc) | Mouse | E. coli |
May contribute to the degradation of peptide hormones and be involved in the inactivation of neuronal peptides. | |||
TMPH-01079 | CLN5 Protein, Human, Recombinant (His) | Human | E. coli |
Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal memb... | |||
TMPH-00928 | APBA2 Protein, Human, Recombinant (E. coli, His & Myc) | Human | E. coli |
APBA2 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli. | |||
TMPH-00929 | APBA2 Protein, Human, Recombinant (His & Myc) | Human | HEK293 Cells |
Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the amyloid-beta precursor protein (APP) and hence fo... | |||
TMPJ-00722 | APBA3 Protein, Human, Recombinant (His) | Human | E. coli |
Amyloid β A4 Precursor Protein-Binding Family A Member 3 (APBA3) is an adapter protein that belongs to the X11 family. APBA3 contains 2 PDZ (DHR) domains and 1 PID domain and interacts with the Alzheimer's disease amyloi... | |||
TMPJ-01052 | DYNLL1 Protein, Human, Recombinant (His) | Human | E. coli |
Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a conformation necessary activity, an... | |||
TMPY-05510 | BDNF Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. B... | |||
TMPY-04069 | Neurotrophin 3 Protein, Human, Recombinant | Human | E. coli |
NTF3 (Neurotrophin 3) is a Protein Coding gene. The protein encoded by this gene is a member of the neurotrophin family, that controls the survival and differentiation of mammalian neurons. This protein is closely relate... | |||
TMPH-01031 | CAPN2 Protein, Human, Recombinant (His) | Human | E. coli |
Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226'. Proteolytically cle... | |||
TMPJ-01468 | Pro-Beta NGF Protein, Human, Recombinant | Human | E. coli |
The precursor form of the nerve growth factor (proNGF) like its mature form is characterized by the cystin knot motif consisting of three cystine bridges, whereas proneurotrophins and mature neurotrophins elicit opposite... | |||
TMPJ-00090 | FGF-9 Protein, Human, Recombinant | Human | E. coli |
Fibroblast Growth Factor 9 (FGF-9) belongs to the Fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, inc... | |||
TMPY-05054 | Notch 4 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
NOTCH4 (Notch Receptor 4) is a Protein Coding gene. Notch4 belongs to a family of transmembrane receptors that play an important role in vascular development and maintenance. The NOTCH4 gene is located at 6p21.3 and is i... | |||
TMPY-03425 | Tau Protein, Human, Recombinant (His) | Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are... | |||
TMPJ-00037 | FGF-2 Protein, Mouse, Recombinant | Mouse | E. coli |
FGF basic is one of 22 mitogenic proteins of the FGF family, which show 35-60% amino acid conservation. Unlike other FGFs, FGF acidic and basic lack signal peptides and are secreted by an alternate pathway. The 17 kDa mo... | |||
TMPY-01355 | Transglutaminase 2/TGM2 Protein, Human, Recombinant (His) | Human | Baculovirus Insect Cells |
Protein-glutamine gamma-glutamyltransferase 2, also known as Tissue transglutaminase, Transglutaminase C, Transglutaminase-2, and TGM2, is a member of the transglutaminase superfamily. TGM2 plays a role in cell growth an... | |||
TMPJ-01011 | FGF-9 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine a... | |||
TMPY-02245 | SNAP-25 Protein, Human, Recombinant (His) | Human | E. coli |
Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains... | |||
TMPH-01758 | NEFL Protein, Human, Recombinant | Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot... | |||
TMPH-01760 | NEFM Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot... | |||
TMPH-01759 | NEFL Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot... | |||
TMPH-02805 | NEFL Protein, Mouse, Recombinant (His) | Mouse | P. pastoris (Yeast) |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament prot... | |||
TMPH-03340 | NEFH Protein, Rat, Recombinant (His & Myc) | Rat | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by... | |||
TMPH-03754 | NAV1 Protein, Human, Recombinant (His) | Human | E. coli |
May be involved in neuronal migration. | |||
TMPH-01227 | DPYSL2 Protein, Human, Recombinant (His) | Human | P. pastoris (Yeast) |
Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the... | |||
TMPH-01757 | NEFH Protein, Human, Recombinant (His & Myc & SUMO) | Human | E. coli |
Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by... | |||
TMPH-01229 | DPYSL5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
May have a function in neuronal differentiation and/or axon growth. | |||
TMPY-02718 | Doublecortin/DCX Protein, Human, Recombinant (aa 45-150, GST) | Human | E. coli |
DCX (doublecortin, N-GST chimera)contains 2 doublecortin domains and belongs to the doublecortin family. It is highly expressed in neuronal cells of fetal brain, but not expressed in other fetal tissues. In the adult, it... | |||
TMPH-01228 | DPYSL3 Protein, Human, Recombinant (His) | Human | E. coli |
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration. | |||
TMPH-02754 | LGI3 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
May participate in the regulation of neuronal exocytosis. LGI3 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 62.7 kDa and the accession nu... | |||
TMPH-02087 | STK38L Protein, Human, Recombinant (His) | Human | E. coli |
Involved in the regulation of structural processes in differentiating and mature neuronal cells. STK38L Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecula... | |||
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