Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor.
説明 | Indomethacin (Indometacin) is a Nonsteroidal Anti-inflammatory Drug. The mechanism of action of indomethacin is as a Cyclooxygenase Inhibitor. |
ターゲット&IC50 | COX-1:0.28 μM, COX-2:14 μM |
In vitro | In rats, Indomethacin at a dosage of 7.5 mg/kg induces acute damage and inflammation in the distal jejunum and proximal ileum. Oral administration of Indomethacin at 20 mg/kg increases the total area of gastric mucosal erosion and the concentration of lipid peroxides. |
In vivo | Indomethacin modulates TCF activity, thereby reducing the transcription of β-catenin/TCF-responsive genes without disrupting the formation of the β-catenin/TCF complex. |
別名 | Indocin, Indometacine, Indomethacine, Indometacin |
分子量 | 357.79 |
分子式 | C19H16ClNO4 |
CAS No. | 53-86-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (139.75 mM)
Ethanol: 17.9 mg/mL (50 mM)), Heating is recommended.
You can also refer to dose conversion for different animals. 詳細
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Indomethacin 53-86-1 Autophagy Immunology/Inflammation Metabolism Neuroscience Phospholipase COX PDE inflammation Indocin inhibit COX-2 anticancer Indometacine anti-infective Inhibitor Indomethacine Cyclooxygenase Indometacin COX-1 inhibitor