Powder: -20°C for 3 years | In solvent: -80°C for 1 year
EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
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1 mg | 在庫あり | ¥ 22,500 | |||
5 mg | 在庫あり | ¥ 56,000 | |||
10 mg | 在庫あり | ¥ 91,000 | |||
25 mg | 在庫あり | ¥ 155,500 | |||
50 mg | 在庫あり | ¥ 221,000 | |||
100 mg | 在庫あり | ¥ 294,000 | |||
500 mg | 在庫あり | ¥ 594,500 |
説明 | EGFR-IN-7 (TQB3804) is a selective and potent EGFR kinase inhibitor. |
ターゲット&IC50 | EGFR:0.218 nM, EGFR (WT):7.92 nM |
In vitro | TQB3804 displayed potent enzymatic activities for EGFRd746-750/T790M/C797S, EGFRL858R/T790M/C797S, EGFRd746-750/T790M, and EGFRL858R/T790M with IC50 of 0.46, 0.13, 0.26, and 0.19 nM respectively, and has similar enzymatic activity for EGFRWT (IC50 = 1.07) to Osimertinib. It also showed expected anti-proliferative activity in 4 cell lines, Ba/F3 (EGFRd746-750/T790M/C797S), NCI-H1975 (EGFRd746-750/T790M/C797S), PC9 (EGFRd746-750), and A431 (EGFRWT), with IC50 of 26.8, 163, 45, and 147 nM, respectively. |
別名 | TQB3804 |
分子量 | 694.6 |
分子式 | C32H41BrN9O2P |
CAS No. | 2267329-76-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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EGFR-IN-7 2267329-76-8 Angiogenesis JAK/STAT signaling Tyrosine Kinase/Adaptors EGFR HER1 EGFR IN 7 ErbB-1 Inhibitor inhibit Epidermal growth factor receptor TQB 3804 TQB-3804 EGFRIN7 TQB3804 inhibitor