Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 41,000 | |||
25 mg | 在庫あり | ¥ 83,500 | |||
50 mg | 在庫あり | ¥ 133,000 | |||
100 mg | 在庫あり | ¥ 191,500 | |||
500 mg | 在庫あり | ¥ 388,000 |
説明 | GTP-14564 is a novel tyrosine kinase inhibitor that also inhibits wt-FLT3 and ITD-FLT3. GTP-14564 inhibits the growth of interleukin-3-independent Ba/F1 expressing ITD-FLT3 at 3 μ m, whereas a 30-fold higher concentration of GTP-14564 is required to inhibit the FLT3 ligand-dependent growth (wt-FLT3) of Ba/F3 expressing wild-type FLT3. F3 expressing wild-type FLT3 (wt-FLT3). |
ターゲット&IC50 | c-Fms:0.3 µM, ITD-FLT3:0.3 µM, c-Kit:0.3 µM, PDGFRβ:1 µM |
In vitro | GTP-14564 (1 μM) inhibited the growth of interleukin-3-independent Ba/F3 expressing ITD-FLT3, whereas a 30-fold higher concentration of GTP-14564 was required to inhibit FLT3 ligand-dependent growth of Ba/F3 expressing wild type FLT3 (wt-FLT3).[1] |
分子量 | 234.25 |
分子式 | C15H10N2O |
CAS No. | 34823-86-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMF: 27.0 mg/mL (115.2 mM)
DMSO: 27.0 mg/mL (115.2 mM)
You can also refer to dose conversion for different animals. 詳細
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GTP-14564 34823-86-4 Angiogenesis Tyrosine Kinase/Adaptors FLT Tyrosine Kinases GTP14564 GTP 14564 Inhibitor inhibitor inhibit