Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research.
説明 | HDAC-IN-52 is a pyridine-containing HDAC inhibitor that inhibits HDAC1, HDAC2, HDAC3 and HDAC10 with IC50s of 0.189, 0.227, 0.440 and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research. |
ターゲット&IC50 | HDAC10:0.446 μM, HDAC1:0.189 μM, HDAC3:0.440 μM, HDAC2:0.227 μM |
In vitro |
HDAC-IN-52 (72 h) inhibited the proliferation of HCT116, A549 and K562 cells with IC50 values of 0.43, 1.28 and 0.37 μM, respectively.[1 ]. HDAC-IN-52 (1-5 μM ; 24-48 h) significantly induced cell death in leukemic U937 cells after 48 h, with 76% and 100% G1 prophase blockade, respectively.[1 ] HDAC-IN-52 (1-5 μM ; 48 h) increased mRNA expression of p21, BAX and BAK and downregulated cyclin D1 and BCL-2.[1 ] |
分子量 | 396.44 |
分子式 | C24H20N4O2 |
CAS No. | 2075787-77-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (63.06 mM)
You can also refer to dose conversion for different animals. 詳細
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HDAC-IN-52 2075787-77-6 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC Inhibitor inhibitor inhibit